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dc.contributor.authorHui, Christy Lm
dc.contributor.authorHoner, William G
dc.contributor.authorLee, Edwin Hm
dc.contributor.authorChang, WC
dc.contributor.authorChan, Sherry Kw
dc.contributor.authorChen, Emily Sm
dc.contributor.authorPang, Edwin Pf
dc.contributor.authorLui, Simon Sy
dc.contributor.authorChung, Dicky Ws
dc.contributor.authorYeung, WS
dc.contributor.authorNg, Roger Mk
dc.contributor.authorLo, William Tl
dc.contributor.authorJones, Peter
dc.contributor.authorSham, Pak
dc.contributor.authorChen, Eric Yh
dc.date.accessioned2018-12-05T00:30:32Z
dc.date.available2018-12-05T00:30:32Z
dc.date.issued2019-10
dc.identifier.issn0033-2917
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286304
dc.description.abstractBACKGROUND: Although relapse in psychosis is common, a small proportion of patients will not relapse in the long term. We examined the proportion and predictors of patients who never relapsed in the 10 years following complete resolution of positive symptoms from their first psychotic episode. METHOD: Patients who previously enrolled in a 12-month randomized controlled trial on medication discontinuation and relapse following first-episode psychosis (FEP) were followed up after 10 years. Relapse of positive symptoms was operationalized as a change from a Clinical Global Impression scale positive score of <3 for at least 3 consecutive months to a score of ⩾3 (mild or more severe). Baseline predictors included basic demographics, premorbid functioning, symptoms, functioning, and neurocognitive functioning. RESULTS: Out of 178 first-episode patients, 37 (21%) never relapsed during the 10-year period. Univariate predictors (p ⩽ 0.1) of patients who never relapsed included a duration of untreated psychosis (DUP) ⩽30 days, diagnosed with non-schizophrenia spectrum disorders, having less severe negative symptoms, and performing better in logical memory immediate recall and verbal fluency tests. A multivariate logistic regression analysis further suggested that the absence of any relapsing episodes was significantly related to better short-term verbal memory, shorter DUP, and non-schizophrenia spectrum disorders. CONCLUSIONS: Treatment delay and neurocognitive function are potentially modifiable predictors of good long-term prognosis in FEP. These predictors are informative as they can be incorporated into an optimum risk prediction model in the future, which would help with clinical decision making regarding maintenance treatment in FEP.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherCambridge University Press (CUP)
dc.subjectHumans
dc.subjectRecurrence
dc.subjectLogistic Models
dc.subjectRisk Factors
dc.subjectFollow-Up Studies
dc.subjectMemory
dc.subjectPsychotic Disorders
dc.subjectPsychiatric Status Rating Scales
dc.subjectSchizophrenic Psychology
dc.subjectAdult
dc.subjectHong Kong
dc.subjectFemale
dc.subjectMale
dc.subjectRandomized Controlled Trials as Topic
dc.subjectYoung Adult
dc.titlePredicting first-episode psychosis patients who will never relapse over 10 years.
dc.typeArticle
prism.endingPage2214
prism.issueIdentifier13
prism.publicationDate2019
prism.publicationNamePsychol Med
prism.startingPage2206
prism.volume49
dc.identifier.doi10.17863/CAM.33614
dcterms.dateAccepted2018-09-25
rioxxterms.versionofrecord10.1017/S0033291718003070
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-10
dc.contributor.orcidHui, Christy Lm [0000-0001-6912-208X]
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.identifier.eissn1469-8978
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-10-30
rioxxterms.freetoread.startdate2019-10-30


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