IP<sub>3</sub> receptors and store-operated Ca<sup>2+</sup> entry: a license to fill.
Current opinion in cell biology
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Taylor, C., & Machaca, K. (2019). IP<sub>3</sub> receptors and store-operated Ca<sup>2+</sup> entry: a license to fill.. Current opinion in cell biology, 57 1-7. https://doi.org/10.1016/j.ceb.2018.10.001
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are widely expressed intracellular Ca2+ channels that evoke large local increases in cytosolic Ca2+ concentration. By depleting the ER of Ca2+, IP3Rs also activate store-operated Ca2+ entry (SOCE). Immobile IP3Rs close to the plasma membrane (PM) are the only IP3Rs that respond to physiological stimuli. The association of these ‘licensed’ IP3Rs with the ER-PM junctions where STIM interacts with Orai PM Ca2+ channels may define the autonomous functional unit for SOCE. Ca2+ entering cells through SOCE can be delivered directly to specific effectors, or it may reach them only after the Ca2+ has been sequestered by the ER and then released through IP3Rs. This ‘tunnelling’ of Ca2+ through the ER to IP3Rs selectively delivers Ca2+ to different effectors.
Cell Membrane, Endoplasmic Reticulum, Cytosol, Animals, Humans, Calcium, Calcium Signaling, Intracellular Calcium-Sensing Proteins, Inositol 1,4,5-Trisphosphate Receptors
Wellcome Trust BBSRC
Wellcome Trust (101844/Z/13/Z)
External DOI: https://doi.org/10.1016/j.ceb.2018.10.001
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286319
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/