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IP3 receptors and store-operated Ca2+ entry: a license to fill.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Taylor, Colin W 
Machaca, Khaled 

Abstract

Inositol 1,4,5-trisphosphate receptors (IP3Rs) are widely expressed intracellular Ca2+ channels that evoke large local increases in cytosolic Ca2+ concentration. By depleting the ER of Ca2+, IP3Rs also activate store-operated Ca2+ entry (SOCE). Immobile IP3Rs close to the plasma membrane (PM) are the only IP3Rs that respond to physiological stimuli. The association of these 'licensed' IP3Rs with the ER-PM junctions where STIM interacts with Orai PM Ca2+ channels may define the autonomous functional unit for SOCE. Ca2+ entering cells through SOCE can be delivered directly to specific effectors, or it may reach them only after the Ca2+ has been sequestered by the ER and then released through IP3Rs. This 'tunnelling' of Ca2+ through the ER to IP3Rs selectively delivers Ca2+ to different effectors.

Description

Keywords

Animals, Calcium, Calcium Signaling, Cell Membrane, Cytosol, Endoplasmic Reticulum, Humans, Inositol 1,4,5-Trisphosphate Receptors, Intracellular Calcium-Sensing Proteins

Journal Title

Curr Opin Cell Biol

Conference Name

Journal ISSN

0955-0674
1879-0410

Volume Title

57

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (101844/Z/13/Z)
Biotechnology and Biological Sciences Research Council (BB/P005330/1)
Wellcome Trust BBSRC