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dc.contributor.authorJackson, Stacey AW
dc.contributor.authorHorst, Nicole K
dc.contributor.authorAxelsson, Sebastian FA
dc.contributor.authorHoriguchi, Naotaka
dc.contributor.authorCockcroft, Gemma J
dc.contributor.authorRobbins, Trevor W
dc.contributor.authorRoberts, Angela C
dc.date.accessioned2018-12-07T00:30:31Z
dc.date.available2018-12-07T00:30:31Z
dc.date.issued2019-01-01
dc.identifier.issn1047-3211
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286377
dc.description.abstractFronto-striatal circuitry involving the orbitofrontal cortex has been identified as mediating successful reversal of stimulus-outcome contingencies. The region of the striatum that most contributes to reversal learning remains unclear, with studies in primates implicating both caudate nucleus and putamen. We trained four marmosets on a touchscreen-based serial reversal task and implanted each with cannulae targeting both putamen and caudate bilaterally. This allowed reversible inactivation of the two areas within the same monkeys, but across separate sessions, to directly investigate their respective contributions to reversal performance. Behavioral sensitivity to the GABAA agonist muscimol varied across subjects and between brain regions, so each marmoset received a range of doses. Intermediate doses of intra-putamen muscimol selectively impaired reversal performance, leaving the baseline discrimination phase unchanged. There was no effect of low doses and high doses were generally disruptive. By contrast, low doses of intra-caudate muscimol improved reversal performance, while high doses impaired both reversal and baseline discrimination performance. These data provide evidence for a specific role of the putamen in serial reversal learning, which may reflect the more habitual nature of repeated reversals using the same stimulus pair.
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectPutamen
dc.subjectAnimals
dc.subjectCallithrix
dc.subjectPhotic Stimulation
dc.subjectDiscrimination Learning
dc.subjectReversal Learning
dc.subjectMale
dc.titleSelective Role of the Putamen in Serial Reversal Learning in the Marmoset.
dc.typeArticle
prism.endingPage460
prism.issueIdentifier1
prism.publicationDate2019
prism.publicationNameCereb Cortex
prism.startingPage447
prism.volume29
dc.identifier.doi10.17863/CAM.33690
dcterms.dateAccepted2018-10-08
rioxxterms.versionofrecord10.1093/cercor/bhy276
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-01
dc.contributor.orcidHorst, Nicole [0000-0002-7145-8911]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.contributor.orcidRoberts, Angela [0000-0003-2873-157X]
dc.identifier.eissn1460-2199
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (104631/Z/14/Z)
pubs.funder-project-idMedical Research Council (G1000183)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
pubs.funder-project-idMedical Research Council (MR/J012084/1)
pubs.funder-project-idMedical Research Council (G0001354)
cam.issuedOnline2018-11-03
datacite.issupplementedby.urlhttps://doi.org/10.17863/CAM.31528
cam.orpheus.successThu Jan 30 10:53:45 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International