Show simple item record

dc.contributor.authorZwakenberg, Sabine R
dc.contributor.authorRemmelzwaal, Sharon
dc.contributor.authorBeulens, Joline WJ
dc.contributor.authorBooth, Sarah L
dc.contributor.authorBurgess, Stephen
dc.contributor.authorDashti, Hassan S
dc.contributor.authorImamura, Fumiaki
dc.contributor.authorFeskens, Edith JM
dc.contributor.authorvan der Schouw, Yvonne T
dc.contributor.authorSluijs, Ivonne
dc.date.accessioned2018-12-07T00:30:46Z
dc.date.available2018-12-07T00:30:46Z
dc.date.issued2019-01
dc.identifier.issn0012-1797
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286386
dc.description.abstractThis study investigated the causal relation between circulating phylloquinone (vitamin K1) concentrations and type 2 diabetes by using a Mendelian randomization (MR) approach. We used data from three studies: the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, Diabetes Genetics Replication and Meta-analysis (DIAGRAM), and the UK Biobank, resulting in 69,647 subjects with type 2 diabetes. We calculated a weighted genetic risk score including four genetic variants previously found to be associated with circulating phylloquinone concentrations. Inverse-variance weighted analysis was used to obtain a risk ratio (RR) for the causal relation between circulating phylloquinone concentrations and risk of type 2 diabetes. Presence of pleiotropy and the robustness of the results were assessed using MR-Egger and weighted-median analyses. Genetically predicted concentrations of circulating phylloquinone were associated with lower risk of type 2 diabetes with an RR of 0.93 (95% CI 0.89; 0.97) per every natural logarithm (Ln)-nmol/L-unit increase in circulating phylloquinone. The MR-Egger and weighted median analyses showed RRs of 0.94 (0.86; 1.02) and 0.93 (0.88; 0.98), respectively, indicating no pleiotropy. In conclusion, our study supports that higher circulating phylloquinone may be causally related with lower risk of type 2 diabetes, highlighting the importance of sufficient phylloquinone in the human diet.
dc.description.sponsorshipFunding for the EPIC-InterAct project was provided by the EU FP6 programme (grant number LSHM_CT_2006_037197). This research has been conducted using the UK Biobank Resource (application number 9161, 9905, 12885 and 20684). SRZ and JWJB are supported by the Senior Dr. Dekker grant (2013T120) from The Dutch Heart Foundation. IS is supported by a personal Dr. Dekker Junior Postdoctoral grant (2015T19) from The Dutch Heart Foundation. FI is supported by MRC Epidemiology Unit Core Grant (MC_UU_12015/5). SLB is partially supported by the USDA Agricultural Research Service cooperative agreement 58-1950-7-707.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherAmerican Diabetes Association
dc.subjectHumans
dc.subjectDiabetes Mellitus, Type 2
dc.subjectGenetic Predisposition to Disease
dc.subjectVitamin K 1
dc.subjectRisk Factors
dc.subjectCohort Studies
dc.subjectProspective Studies
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectMendelian Randomization Analysis
dc.titleCirculating Phylloquinone Concentrations and Risk of Type 2 Diabetes: A Mendelian Randomization Study.
dc.typeArticle
prism.endingPage225
prism.issueIdentifier1
prism.publicationDate2019
prism.publicationNameDiabetes
prism.startingPage220
prism.volume68
dc.identifier.doi10.17863/CAM.33699
dcterms.dateAccepted2018-10-12
rioxxterms.versionofrecord10.2337/db18-0543
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-01
dc.contributor.orcidZwakenberg, Sabine R [0000-0003-1599-3984]
dc.contributor.orcidBurgess, Stephen [0000-0001-5365-8760]
dc.contributor.orcidDashti, Hassan S [0000-0002-1650-679X]
dc.contributor.orcidImamura, Fumiaki [0000-0002-6841-8396]
dc.contributor.orcidSluijs, Ivonne [0000-0001-7758-4911]
dc.identifier.eissn1939-327X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/5)
pubs.funder-project-idWellcome Trust (204623/Z/16/Z)
pubs.funder-project-idMedical Research Council (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idMedical Research Council (MC_UU_00002/7)
cam.issuedOnline2018-10-23


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record