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dc.contributor.authorVogt, Katja L
dc.contributor.authorSummers, Charlotte
dc.contributor.authorCondliffe, Alison M
dc.date.accessioned2018-12-07T00:31:15Z
dc.date.available2018-12-07T00:31:15Z
dc.date.issued2019-01
dc.identifier.issn1065-6251
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286404
dc.description.abstractPURPOSE OF REVIEW: Neutrophils priming has been long studied in vitro. Recent studies describe it in vivo. In pathophysiological conditions, complex, heterogeneous characteristics of priming are described in the last few years. RECENT FINDINGS: Priming can occur systemically when insults such as sepsis or trauma result in an array of circulating mediators and circulating primed neutrophils seem to exert detrimental effects either directly, or indirectly by interacting with other cells, thereby contributing to the development of organ dysfunction. Local priming of neutrophils augments their ability to clear infection, but may also lead to local bystander tissue injury, for example, in the inflamed joint. The complexity, heterogeneity and dynamic nature of inflammatory responses and the accessibility of cells from local sites make neutrophil priming challenging to study in human disease; however, recent advances have made significant progress to this field. SUMMARY: Herein, we summarize the literature regarding neutrophil priming in selected conditions. In some diseases and in the setting of specific genetic influences, the priming repertoire seems to be restricted, with only some neutrophil functions upregulated. A greater understanding of the nature of neutrophil priming and its role in human disease is required before this process becomes tractable to therapeutic intervention.
dc.description.sponsorshipThe research in the authors laboratories is funded by the MRC (MR/M012328; MR/P502091/1), British Lung Foundation (PRG16-13), Wellcome Trust, GlaxoSmithKline plc and NIHR Cambridge Biomedical Research Centre.
dc.format.mediumPrint
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.subjectNeutrophils
dc.subjectHumans
dc.subjectInflammation
dc.subjectNeutrophil Activation
dc.subjectInfections
dc.titleThe clinical consequences of neutrophil priming.
dc.typeArticle
prism.endingPage27
prism.issueIdentifier1
prism.publicationDate2019
prism.publicationNameCurr Opin Hematol
prism.startingPage22
prism.volume26
dc.identifier.doi10.17863/CAM.33715
dcterms.dateAccepted2018-10-18
rioxxterms.versionofrecord10.1097/MOH.0000000000000471
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-01
dc.contributor.orcidSummers, Charlotte [0000-0002-7269-2873]
dc.identifier.eissn1531-7048
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/M012328/1)
rioxxterms.freetoread.startdate2019-11-01


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