MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases.
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Authors
Smith, Anthony C
Robinson, Alan J
Publication Date
2019-01-08Journal Title
Nucleic Acids Res
ISSN
0305-1048
Publisher
Oxford University Press (OUP)
Volume
47
Issue
D1
Pages
D1225-D1228
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print
Metadata
Show full item recordCitation
Smith, A. C., & Robinson, A. J. (2019). MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases.. Nucleic Acids Res, 47 (D1), D1225-D1228. https://doi.org/10.1093/nar/gky1072
Abstract
Increasing numbers of diseases are associated with mitochondrial dysfunction. This is unsurprising given mitochondria have major roles in bioenergy generation, signalling, detoxification, apoptosis and biosynthesis. However, fundamental questions of mitochondrial biology remain, including: which nuclear genes encode mitochondrial proteins; how their expression varies with tissue; and which are associated with disease. But experiments to catalogue the mitochondrial proteome are incomplete and sometimes contradictory. This arises because the mitochondrial proteome has tissue- and stage-specific variability, plus differences among experimental techniques and localization evidence types used. This leads to limitations in each technique's coverage and inevitably conflicting results. To support identification of mitochondrial proteins, we developed MitoMiner (http://mitominer.mrc-mbu.cam.ac.uk/), a database combining evidence of mitochondrial localization with information from public resources. Here we report upgrades to MitoMiner, including its re-engineering to be gene-centric to enable easier sharing of evidence among orthologues and support next generation sequencing, plus new data sources, including expression in different tissues, information on phenotypes and diseases of genetic mutations and a new mitochondrial proteome catalogue. MitoMiner is a powerful platform to investigate mitochondrial localization by providing a unique combination of experimental sub-cellular localization datasets, tissue expression, predictions of mitochondrial targeting sequences, gene annotation and links to phenotype and disease.
Keywords
Computational Biology, Data Management, Databases, Factual, High-Throughput Nucleotide Sequencing, Humans, Internet, Mitochondria, Mitochondrial Diseases, Mitochondrial Proteins, Phenotype, Proteome, Proteomics
Sponsorship
Medical Research Council (MC_U105674181)
Identifiers
External DOI: https://doi.org/10.1093/nar/gky1072
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286405
Rights
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/
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