Morphogenetic degeneracies in the actomyosin cortex.
View / Open Files
Authors
Fievet, Bruno Thomas
Grill, Stephan W
Publication Date
2018-10-22Journal Title
Elife
ISSN
2050-084X
Publisher
eLife Sciences Publications, Ltd
Volume
7
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Naganathan, S. R., Fürthauer, S., Rodriguez, J., Fievet, B. T., Jülicher, F., Ahringer, J., Cannistraci, C. V., & et al. (2018). Morphogenetic degeneracies in the actomyosin cortex.. Elife, 7 https://doi.org/10.7554/eLife.37677
Abstract
One of the great challenges in biology is to understand the mechanisms by which morphogenetic processes arise from molecular activities. We investigated this problem in the context of actomyosin-based cortical flow in C. elegans zygotes, where large-scale flows emerge from the collective action of actomyosin filaments and actin binding proteins (ABPs). Large-scale flow dynamics can be captured by active gel theory by considering force balances and conservation laws in the actomyosin cortex. However, which molecular activities contribute to flow dynamics and large-scale physical properties such as viscosity and active torque is largely unknown. By performing a candidate RNAi screen of ABPs and actomyosin regulators we demonstrate that perturbing distinct molecular processes can lead to similar flow phenotypes. This is indicative for a 'morphogenetic degeneracy' where multiple molecular processes contribute to the same large-scale physical property. We speculate that morphogenetic degeneracies contribute to the robustness of bulk biological matter in development.
Keywords
C. elegans, RNAi screen, actomyosin, cell biology, cortical flow, degeneracy, hydrodynamics, physics of living systems, Actins, Actomyosin, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Embryo, Nonmammalian, Fluorescence, Hydrodynamics, Microfilament Proteins, Models, Biological, Morphogenesis, Myosins, RNA Interference, Rheology
Sponsorship
Wellcome Trust (084598/Z/07/Z)
Wellcome Trust (101863/Z/13/Z)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (641639)
Identifiers
External DOI: https://doi.org/10.7554/eLife.37677
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286526
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk