Drinking pattern during midlife and risk of developing depression during 28 years of follow-up: A prospective cohort study.
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Publication Date
2015-10-01Journal Title
Drug Alcohol Depend
ISSN
0376-8716
Publisher
Elsevier BV
Volume
155
Pages
111-117
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Bell, S., & Britton, A. (2015). Drinking pattern during midlife and risk of developing depression during 28 years of follow-up: A prospective cohort study.. Drug Alcohol Depend, 155 111-117. https://doi.org/10.1016/j.drugalcdep.2015.08.008
Abstract
BACKGROUND: The long-term impact of alcohol intake in midlife on developing depression is not clear. We aimed to investigate drinking pattern during midlife as a risk factor for developing depression during 28 years of follow-up. METHODS: We used data from a well characterised prospective cohort study (the Whitehall II study) of 7478 men and women (70% male) aged 35 to 55 years, and free from depression in 1985-1988, followed up regularly until 2013. Drinking pattern was defined in terms of usual and maximum amounts consumed within a single drinking session, total weekly volume of alcohol consumed and drinking frequency. Depression was assessed using the General Health Questionnaire Depression Subscale at multiple follow-up occasions (up to eight times in total). Associations between different drinking pattern components during midlife and depression were estimated using flexible parametric survival models. RESULTS: After adjustment for confounding factors only abstaining from alcohol during midlife was associated with an increased risk of developing depression during long-term observation. However, this association became non-significant after adjusting for baseline self-reported health. CONCLUSIONS: In this community dwelling population, drinking pattern during midlife was not associated with an increased risk of developing depression.
Keywords
Humans, Risk Factors, Follow-Up Studies, Prospective Studies, Depression, Alcohol Drinking, Adult, Middle Aged, England, Female, Male
Sponsorship
Medical Research Council (MR/M006638/1)
Identifiers
External DOI: https://doi.org/10.1016/j.drugalcdep.2015.08.008
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286544
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