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dc.contributor.authorBell, Steven
dc.contributor.authorBritton, Annie
dc.date.accessioned2018-12-08T00:31:23Z
dc.date.available2018-12-08T00:31:23Z
dc.date.issued2015-10-01
dc.identifier.issn0376-8716
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286544
dc.description.abstractBACKGROUND: The long-term impact of alcohol intake in midlife on developing depression is not clear. We aimed to investigate drinking pattern during midlife as a risk factor for developing depression during 28 years of follow-up. METHODS: We used data from a well characterised prospective cohort study (the Whitehall II study) of 7478 men and women (70% male) aged 35 to 55 years, and free from depression in 1985-1988, followed up regularly until 2013. Drinking pattern was defined in terms of usual and maximum amounts consumed within a single drinking session, total weekly volume of alcohol consumed and drinking frequency. Depression was assessed using the General Health Questionnaire Depression Subscale at multiple follow-up occasions (up to eight times in total). Associations between different drinking pattern components during midlife and depression were estimated using flexible parametric survival models. RESULTS: After adjustment for confounding factors only abstaining from alcohol during midlife was associated with an increased risk of developing depression during long-term observation. However, this association became non-significant after adjusting for baseline self-reported health. CONCLUSIONS: In this community dwelling population, drinking pattern during midlife was not associated with an increased risk of developing depression.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.subjectHumans
dc.subjectRisk Factors
dc.subjectFollow-Up Studies
dc.subjectProspective Studies
dc.subjectDepression
dc.subjectAlcohol Drinking
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectEngland
dc.subjectFemale
dc.subjectMale
dc.titleDrinking pattern during midlife and risk of developing depression during 28 years of follow-up: A prospective cohort study.
dc.typeArticle
prism.endingPage117
prism.publicationDate2015
prism.publicationNameDrug Alcohol Depend
prism.startingPage111
prism.volume155
dc.identifier.doi10.17863/CAM.33854
dcterms.dateAccepted2015-08-10
rioxxterms.versionofrecord10.1016/j.drugalcdep.2015.08.008
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-10
dc.contributor.orcidBell, Steven [0000-0001-6774-3149]
dc.identifier.eissn1879-0046
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/M006638/1)
cam.issuedOnline2015-08-19
rioxxterms.freetoread.startdate2016-10-31


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