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dc.contributor.authorKnott, Craigen
dc.contributor.authorBell, Stevenen
dc.contributor.authorBritton, Annieen
dc.date.accessioned2018-12-08T00:31:31Z
dc.date.available2018-12-08T00:31:31Z
dc.date.issued2015-09-01en
dc.identifier.issn0149-5992
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286550
dc.description.abstractOBJECTIVE: Observational studies indicate that moderate levels of alcohol consumption may reduce the risk of type 2 diabetes. In addition to providing an updated summary of the existing literature, this meta-analysis explored whether reductions in risk may be the product of misclassification bias. RESEARCH DESIGN AND METHODS: A systematic search was undertaken, identifying studies that reported a temporal association between alcohol consumption and the risk of type 2 diabetes. No restrictions were placed upon the language or date of publication. Non-English publications were, where necessary, translated using online translation tools. Models were constructed using fractional polynomial regression to determine the best-fitting dose-response relationship between alcohol intake and type 2 diabetes, with a priori testing of sex and referent group interactions. RESULTS: Thirty-eight studies met the selection criteria, representing 1,902,605 participants and 125,926 cases of type 2 diabetes. A conventional noncurrent drinking category was reported by 33 studies, while five reported a never-drinking category. Relative to combined abstainers, reductions in the risk of type 2 diabetes were present at all levels of alcohol intake <63 g/day, with risks increasing above this threshold. Peak risk reduction was present between 10-14 g/day at an 18% decrease in hazards. Stratification of available data revealed that reductions in risk may be specific to women only and absent in studies that adopted a never-drinking abstention category or sampled an Asian population region. CONCLUSIONS: Reductions in risk among moderate alcohol drinkers may be confined to women and non-Asian populations. Although based on a minority of studies, there is also the possibility that reductions in risk may have been overestimated by studies using a referent group contaminated by less healthy former drinkers.
dc.description.sponsorshipC.K., S.B., and A.B. are funded by the European Research Council (ERC-StG-2012-309337_AlcoholLifecourse; principal investigator A.B. [http://www.ucl.ac.uk/alcohol-lifecourse]) and the U.K. Medical Research Council/Alcohol Research UK (MR/M006638/1).
dc.languageengen
dc.publisherAmerican Diabetes Association
dc.subjectAdulten
dc.subjectAlcohol Drinkingen
dc.subjectBlood Glucoseen
dc.subjectDiabetes Mellitus, Type 2en
dc.subjectEthanolen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectRisk Factorsen
dc.subjectSex Factorsen
dc.titleAlcohol Consumption and the Risk of Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of More Than 1.9 Million Individuals From 38 Observational Studies.en
dc.typeArticle
prism.endingPage1812
prism.issueIdentifier9en
prism.publicationDate2015en
prism.publicationNameDiabetes Careen
prism.startingPage1804
prism.volume38en
dc.identifier.doi10.17863/CAM.33860
dcterms.dateAccepted2015-06-09en
rioxxterms.versionofrecord10.2337/dc15-0710en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-09-01en
dc.contributor.orcidBell, Steven [0000-0001-6774-3149]
dc.identifier.eissn1935-5548
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2015-08-20en
rioxxterms.freetoread.startdate2016-08-20


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