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dc.contributor.authorChu, Alexander L
dc.contributor.authorStochl, Jan
dc.contributor.authorLewis, Glyn
dc.contributor.authorZammit, Stan
dc.contributor.authorJones, Peter B
dc.contributor.authorKhandaker, Golam M
dc.date.accessioned2018-12-11T00:31:39Z
dc.date.available2018-12-11T00:31:39Z
dc.date.issued2019-02
dc.identifier.issn0889-1591
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286648
dc.description.abstractBACKGROUND: Low-grade inflammation is associated with depression, but studies of specific symptoms are relatively scarce. Association between inflammatory markers and specific symptoms may provide insights into potential mechanism of inflammation-related depression. Using longitudinal data, we have tested whether childhood serum interleukin 6 (IL-6) and C-reactive protein (CRP) levels are associated with specific depressive symptoms in early adulthood. METHODS: In the ALSPAC birth cohort, serum IL-6 and CRP levels were assessed at age 9 years and 19 depressive symptoms were assessed at age 18 years. We used modified Poisson generalised linear regression with robust error variance to estimate the risk ratio (RR) and 95% confidence interval (95% CI) for each depressive symptom. In addition, we used confirmatory factor analysis to create two continuous latent variables representing somatic/neurovegetative and psychological dimension scores. Structural equation modelling was used to test the associations between IL-6 and these dimension scores. RESULTS: Based on data from 2731 participants, IL-6 was associated with diurnal mood variation, concentration difficulties, fatigue and sleep disturbances. The adjusted RRs for these symptoms at age 18 years for participants in top, compared with bottom, third of IL-6 at age 9 years were 1.75 (95% CI, 1.13-2.69) for diurnal mood variation, 1.50 (95% CI, 1.11-2.02) for concentration difficulties, 1.31 (95% CI, 1.12-1.54) for fatigue, and 1.24 (95% CI, 1.01-1.52) for sleep disturbances. At dimension level, IL-6 was associated with both somatic/neurovegetative (β = 0.059, SE = 0.024, P = 0.013) and psychological (β = 0.056, SE = 0.023, P = 0.016) scores. CONCLUSIONS: Inflammation is associated with specific symptoms of depression. Associations with so-called somatic/neurovegetative symptoms of depression such as fatigue, sleep disturbances and diurnal mood variation indicate that these symptoms could be useful treatment targets and markers of treatment response in clinical trials of anti-inflammatory treatment for depression.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectInflammation
dc.subjectFatigue
dc.subjectC-Reactive Protein
dc.subjectAnti-Inflammatory Agents
dc.subjectInterleukin-6
dc.subjectCohort Studies
dc.subjectLongitudinal Studies
dc.subjectProspective Studies
dc.subjectDepression
dc.subjectDepressive Disorder
dc.subjectAdolescent
dc.subjectChild
dc.subjectEngland
dc.subjectFemale
dc.subjectMale
dc.subjectBiomarkers
dc.titleLongitudinal association between inflammatory markers and specific symptoms of depression in a prospective birth cohort.
dc.typeArticle
prism.endingPage81
prism.publicationDate2019
prism.publicationNameBrain Behav Immun
prism.startingPage74
prism.volume76
dc.identifier.doi10.17863/CAM.33960
dcterms.dateAccepted2018-11-06
rioxxterms.versionofrecord10.1016/j.bbi.2018.11.007
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-02
dc.contributor.orcidStochl, Jan [0000-0002-9693-9930]
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.contributor.orcidKhandaker, Golam [0000-0002-4935-9220]
dc.identifier.eissn1090-2139
rioxxterms.typeJournal Article/Review
pubs.funder-project-idAcademy of Medical Sciences (unknown)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (BRC 2012-2017)
pubs.funder-project-idWellcome Trust (201486/Z/16/Z)
pubs.funder-project-idWellcome Trust (088869/Z/09/Z)
pubs.funder-project-idWellcome Trust (095844/Z/11/Z)
pubs.funder-project-idMQ: Transforming Mental Health (MQDS17\40)
pubs.funder-project-idNational Institute for Health Research (RP-PG-0606-1335)
cam.issuedOnline2018-11-07


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International