Subtractive non-contrast-enhanced MRI of lower limb veins using multiple flow-dependent preparation strategies.
Magnetic resonance in medicine
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Li, H., Priest, A. N., Patterson, I., Graves, M., & Lomas, D. (2019). Subtractive non-contrast-enhanced MRI of lower limb veins using multiple flow-dependent preparation strategies.. Magnetic resonance in medicine, 81 (3), 1769-1783. https://doi.org/10.1002/mrm.27530
Purpose: To evaluate the performance of Acceleration-Dependent Vascular Anatomy for Non-Contrast-Enhanced MR Venography (ADVANCE-MRV) in femoral veins and investigate whether venous signal uniformity can be improved by applying multiple acquisitions with different flow-suppressions or multiple flow-suppressions in one acquisition. Method: ADVANCE-MRV uses flow-sensitised modules to acquire a dark-artery image set and a dark-artery-vein set, which are subsequently subtracted. Ten healthy volunteers were imaged, using the ADVANCE-MRV sequence with improved venous suppression uniformity in the dark-artery-vein images achieved by applying multiple flow-suppressions in the same acquisition or by combining multiple images acquired with different flow-suppressions. The performance of the improved technique was also evaluated in thirteen patients with lower-limb deep venous thrombosis (DVT). Results: Multiple-preparation and multiple-acquisition approaches all improved venous signal uniformity and reduced the signal void artefacts observed in the original ADVANCE-MRV images. The multiple-acquisition approaches achieved excellent blood signal uniformity and intensity, albeit at the cost of an increase in the total acquisition time. The double-preparation approach demonstrated good performance in all measurements, providing a good compromise between signal uniformity and acquisition time. The blood signal spatial variation and its variation using different gradient amplitudes were reduced by 20% and 29%. All patient images showed uniform and bright venous signal in non-occluded sections of vein. Conclusion: The enhanced ADVANCE-MRV methods substantially improved signal uniformity in healthy volunteers and patients with known DVT. The double-preparation approach gave good quality femoral vein images providing improved venous signal uniformity without increasing acquisition time in comparison to the original sequence.
Lower Extremity, Arteries, Veins, Femoral Vein, Popliteal Vein, Humans, Venous Thrombosis, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Angiography, Phlebography, Reproducibility of Results, Algorithms, Motion, Computer Simulation, Adolescent, Adult, Aged, Middle Aged, Female, Male, Young Adult, Healthy Volunteers
Addenbrooke’s Charitable Trust NIHR Cambridge Biomedical Research Centre China Scholarship Council Cambridge Trust
Addenbrooke's Charitable Trust (ACT) (9378)
Cambridge University Hospitals NHS Foundation Trust (CUH) (RG52525)
External DOI: https://doi.org/10.1002/mrm.27530
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286676