A neurosurgical approach to traumatic brain injury and post-traumatic hypopituitarism.
Hutchinson, Peter J
Springer Science and Business Media LLC
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Tan, C. L., & Hutchinson, P. J. (2019). A neurosurgical approach to traumatic brain injury and post-traumatic hypopituitarism.. Pituitary, 22 (3), 332-337. https://doi.org/10.1007/s11102-018-0925-z
PURPOSE: Traumatic brain injury (TBI) is a common cause of mortality and major disability worldwide. The initial management often depends on the severity of the injury. Pituitary dysfunction can develop as a sequela of TBI, and can have long-term, debilitating impact on the patients. Early identification and prompt intervention of post-traumatic hypopituitarism (PTHP) is essential to prevent or minimize the adverse consequences of this condition. We hereby provide an overview of the current management of TBI from a neurosurgical standpoint. We then review the pathophysiology and risk factors of developing PTHP, as well as our recommendations for its management. METHODS: A review of current literature on TBI and PTHP, including primary research articles, reviews and clinical guidelines. RESULTS: The current neurosurgical approach to the management of TBI is presented, followed by the pathophysiology and risk factors of PTHP, as well as our recommendations for its management. CONCLUSIONS: Post-traumatic hypopitutiarism is a serious and potentially debilitating condition that is likely under-recognised and under-diagnosed. From a neurosurgical perspective, we advocate a pragmatic approach, i.e. screening those considered at high risk of developing PTHP based on clinical features and biochemical/endocrinological testings; and referring them to a specialist endocrinologist for further management as indicated.
Humans, Hypopituitarism, Neurosurgery, Brain Injuries, Traumatic
Medical Research Council (G0601025)
Medical Research Council (G1002277)
Medical Research Council (G0600986)
Medical Research Council (G9439390)
External DOI: https://doi.org/10.1007/s11102-018-0925-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286721
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/