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dc.contributor.authorTan, Chin Lik
dc.contributor.authorHutchinson, Peter
dc.date.accessioned2018-12-12T00:31:35Z
dc.date.available2018-12-12T00:31:35Z
dc.date.issued2019-06
dc.identifier.issn1386-341X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286721
dc.description.abstractPURPOSE: Traumatic brain injury (TBI) is a common cause of mortality and major disability worldwide. The initial management often depends on the severity of the injury. Pituitary dysfunction can develop as a sequela of TBI, and can have long-term, debilitating impact on the patients. Early identification and prompt intervention of post-traumatic hypopituitarism (PTHP) is essential to prevent or minimize the adverse consequences of this condition. We hereby provide an overview of the current management of TBI from a neurosurgical standpoint. We then review the pathophysiology and risk factors of developing PTHP, as well as our recommendations for its management. METHODS: A review of current literature on TBI and PTHP, including primary research articles, reviews and clinical guidelines. RESULTS: The current neurosurgical approach to the management of TBI is presented, followed by the pathophysiology and risk factors of PTHP, as well as our recommendations for its management. CONCLUSIONS: Post-traumatic hypopitutiarism is a serious and potentially debilitating condition that is likely under-recognised and under-diagnosed. From a neurosurgical perspective, we advocate a pragmatic approach, i.e. screening those considered at high risk of developing PTHP based on clinical features and biochemical/endocrinological testings; and referring them to a specialist endocrinologist for further management as indicated.
dc.description.sponsorshipNIHR
dc.format.mediumPrint
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectHypopituitarism
dc.subjectNeurosurgery
dc.subjectBrain Injuries, Traumatic
dc.titleA neurosurgical approach to traumatic brain injury and post-traumatic hypopituitarism.
dc.typeArticle
prism.endingPage337
prism.issueIdentifier3
prism.publicationDate2019
prism.publicationNamePituitary
prism.startingPage332
prism.volume22
dc.identifier.doi10.17863/CAM.34028
dcterms.dateAccepted2018-10-28
rioxxterms.versionofrecord10.1007/s11102-018-0925-z
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-06
dc.contributor.orcidTan, Chin Lik [0000-0002-3877-7347]
dc.contributor.orcidHutchinson, Peter [0000-0002-2796-1835]
dc.identifier.eissn1573-7403
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G0601025)
pubs.funder-project-idMedical Research Council (G1002277)
pubs.funder-project-idMedical Research Council (G0600986)
pubs.funder-project-idMedical Research Council (G9439390)
pubs.funder-project-idNETSCC (None)
pubs.funder-project-idNETSCC (None)
pubs.funder-project-idTCC (None)
cam.issuedOnline2018-11-27


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International