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dc.contributor.authorHanly, John Gen
dc.contributor.authorLi, Qiujuen
dc.contributor.authorSu, Lien
dc.contributor.authorUrowitz, Murray Ben
dc.contributor.authorGordon, Carolineen
dc.contributor.authorBae, Sang-Cheolen
dc.contributor.authorRomero-Diaz, Juanitaen
dc.contributor.authorSanchez-Guerrero, Jorgeen
dc.contributor.authorBernatsky, Sashaen
dc.contributor.authorClarke, Ann Een
dc.contributor.authorWallace, Daniel Jen
dc.contributor.authorIsenberg, David Aen
dc.contributor.authorRahman, Anisuren
dc.contributor.authorMerrill, Joan Ten
dc.contributor.authorFortin, Paul Ren
dc.contributor.authorGladman, Dafna Den
dc.contributor.authorBruce, Ian Nen
dc.contributor.authorPetri, Michelleen
dc.contributor.authorGinzler, Ellen Men
dc.contributor.authorDooley, MAen
dc.contributor.authorSteinsson, Kristjanen
dc.contributor.authorRamsey-Goldman, Rosalinden
dc.contributor.authorZoma, Asad Aen
dc.contributor.authorManzi, Susanen
dc.contributor.authorNived, Olaen
dc.contributor.authorJonsen, Andreasen
dc.contributor.authorKhamashta, Munther Aen
dc.contributor.authorAlarcón, Graciela Sen
dc.contributor.authorvan Vollenhoven, Ronald Fen
dc.contributor.authorAranow, Cynthiaen
dc.contributor.authorMackay, Megganen
dc.contributor.authorRuiz-Irastorza, Guillermoen
dc.contributor.authorRamos-Casals, Manuelen
dc.contributor.authorLim, S Samen
dc.contributor.authorInanc, Muraten
dc.contributor.authorKalunian, Kenneth Cen
dc.contributor.authorJacobsen, Sorenen
dc.contributor.authorPeschken, Christine Aen
dc.contributor.authorKamen, Diane Len
dc.contributor.authorAskanase, Ancaen
dc.contributor.authorTheriault, Chrisen
dc.contributor.authorFarewell, Vernonen
dc.date.accessioned2018-12-13T00:30:40Z
dc.date.available2018-12-13T00:30:40Z
dc.date.issued2019-02en
dc.identifier.issn2326-5191
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286774
dc.description.abstractOBJECTIVES: To determine, in a multi-ethnic/racial, prospective SLE inception cohort, the frequency, attribution, clinical and autoantibody associations with lupus psychosis and the short and long-term outcome as assessed by physicians and patients. METHODS: Patients were evaluated annually for 19 neuropsychiatric (NP) events including psychosis. SLE disease activity 2000, SLICC/ACR damage index and SF-36 scores were collected. Time to event and linear regressions were used as appropriate. RESULTS: Of 1,826 SLE patients, 88.8% were female, 48.8% Caucasian. The mean±SD age was 35.1±13.3 years, disease duration 5.6±4.2 months and follow-up 7.4±4.5 years. There were 31 psychotic events in 28/1,826 (1.53%) patients and most [(26/28; 93%)] had a single event. In the majority of patients [20/25; (80%)] and events [28/31; (90%)] psychosis was attributed to SLE, usually within 3 years of SLE diagnosis. Positive associations [hazard ratio and 95% confidence interval [HR (95%CI)] with lupus psychosis were prior SLE NP events [3.59, (1.16, 11.14), male sex [3.0, (1.20, 7.50)], younger age at SLE diagnosis [(per 10 years younger), 1.45 (1.01, 2.07)] and African ancestry [4.59 (1.79, 11.76)]. By physician assessment most psychotic events resolved by the second annual visit following onset, in parallel with an improvement in patient reported SF-36 summary and subscale scores. CONCLUSION: Psychosis is an infrequent manifestation of NPSLE. Generally, it occurs early after SLE onset and has a significant negative impact on health status. As determined by patient and physician report, the short and long term outlook is good for most patients, though careful follow-up is required. This article is protected by copyright. All rights reserved.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.subjectHumansen
dc.subjectLupus Vasculitis, Central Nervous Systemen
dc.subjectLupus Erythematosus, Systemicen
dc.subjectReceptors, N-Methyl-D-Aspartateen
dc.subjectLupus Coagulation Inhibitoren
dc.subjectAutoantibodiesen
dc.subjectAntibodies, Anticardiolipinen
dc.subjectLinear Modelsen
dc.subjectProportional Hazards Modelsen
dc.subjectCohort Studiesen
dc.subjectProspective Studiesen
dc.subjectPsychotic Disordersen
dc.subjectAge Factorsen
dc.subjectSex Factorsen
dc.subjectAdulten
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectbeta 2-Glycoprotein Ien
dc.subjectYoung Adulten
dc.subjectKaplan-Meier Estimateen
dc.titlePsychosis in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study.en
dc.typeArticle
prism.endingPage289
prism.issueIdentifier2en
prism.publicationDate2019en
prism.publicationNameArthritis & rheumatology (Hoboken, N.J.)en
prism.startingPage281
prism.volume71en
dc.identifier.doi10.17863/CAM.34081
dcterms.dateAccepted2018-10-17en
rioxxterms.versionofrecord10.1002/art.40764en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-02en
dc.contributor.orcidSu, Li [0000-0003-0919-3462]
dc.contributor.orcidUrowitz, Murray B [0000-0001-7506-9166]
dc.contributor.orcidGordon, Caroline [0000-0002-1244-6443]
dc.contributor.orcidBruce, Ian N [0000-0003-3047-500X]
dc.contributor.orcidPetri, Michelle [0000-0003-1441-5373]
dc.contributor.orcidRuiz-Irastorza, Guillermo [0000-0001-7788-1043]
dc.contributor.orcidJacobsen, Soren [0000-0002-5654-4993]
dc.identifier.eissn2326-5205
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (unknown)
rioxxterms.freetoread.startdate2019-10-30


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