Prioritized memory access explains planning and hippocampal replay.
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Publication Date
2018-11Journal Title
Nat Neurosci
ISSN
1097-6256
Publisher
Springer Science and Business Media LLC
Volume
21
Issue
11
Pages
1609-1617
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Mattar, M. G., & Daw, N. D. (2018). Prioritized memory access explains planning and hippocampal replay.. Nat Neurosci, 21 (11), 1609-1617. https://doi.org/10.1038/s41593-018-0232-z
Abstract
To make decisions, animals must evaluate candidate choices by accessing memories of relevant experiences. Yet little is known about which experiences are considered or ignored during deliberation, which ultimately governs choice. We propose a normative theory predicting which memories should be accessed at each moment to optimize future decisions. Using nonlocal 'replay' of spatial locations in hippocampus as a window into memory access, we simulate a spatial navigation task in which an agent accesses memories of locations sequentially, ordered by utility: how much extra reward would be earned due to better choices. This prioritization balances two desiderata: the need to evaluate imminent choices versus the gain from propagating newly encountered information to preceding locations. Our theory offers a simple explanation for numerous findings about place cells; unifies seemingly disparate proposed functions of replay including planning, learning, and consolidation; and posits a mechanism whose dysfunction may underlie pathologies like rumination and craving.
Keywords
Animals, Behavior, Animal, Decision Making, Hippocampus, Memory, Neurons, Rats, Reward, Spatial Navigation
Identifiers
External DOI: https://doi.org/10.1038/s41593-018-0232-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286789
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Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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