CLN8 safeguards lysosome biogenesis.

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Authors
  Luzio, John
Publication Date
2018-12
Journal Title
Nat Cell Biol
ISSN
1465-7392
Publisher
Springer Science and Business Media LLC
Volume
20
Issue
12
Pages
1333-1335
Language
eng
Type
Article
This Version
AM
Physical Medium
Print
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Citation
Luzio, J. (2018). CLN8 safeguards lysosome biogenesis.. Nat Cell Biol, 20 (12), 1333-1335. https://doi.org/10.1038/s41556-018-0240-y
Abstract
Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.
Keywords
Lysosomes, Endoplasmic Reticulum, Endoplasmic Reticulum Stress
Identifiers
External DOI: https://doi.org/10.1038/s41556-018-0240-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286851
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http://www.rioxx.net/licenses/all-rights-reserved
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