CLN8 safeguards lysosome biogenesis.
Authors
Luzio, J Paul
Change log
Abstract
Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.
Publication Date
2018-12
Online Publication Date
2018-11-05
Acceptance Date
2018-10-23
Keywords
Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Lysosomes
Journal Title
Nat Cell Biol
Journal ISSN
1465-7392
1476-4679
1476-4679
Volume Title
20
Publisher
Springer Science and Business Media LLC