CLN8 safeguards lysosome biogenesis.

Luzio, John

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Authors

Luzio, John

Publication Date

2018-12

Journal Title

Nat Cell Biol

ISSN

1465-7392

Publisher

Springer Science and Business Media LLC

Volume

Issue

Pages

1333-1335

Language

eng

Type

Article

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Citation

Luzio, J. (2018). CLN8 safeguards lysosome biogenesis.. Nat Cell Biol, 20 (12), 1333-1335. https://doi.org/10.1038/s41556-018-0240-y

Abstract

Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.

Keywords

Lysosomes, Endoplasmic Reticulum, Endoplasmic Reticulum Stress

Identifiers

External DOI: https://doi.org/10.1038/s41556-018-0240-y

This record's URL: https://www.repository.cam.ac.uk/handle/1810/286851

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