Repository logo
 

CLN8 safeguards lysosome biogenesis.

Accepted version
Peer-reviewed

No Thumbnail Available

Type

Article

Change log

Authors

Luzio, J Paul 

Abstract

Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.

Description

Keywords

Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Lysosomes

Journal Title

Nat Cell Biol

Conference Name

Journal ISSN

1465-7392
1476-4679

Volume Title

20

Publisher

Springer Science and Business Media LLC