The influence of maternal pregnancy glucose concentrations on associations between a fetal imprinted gene allele score and offspring size at birth.
BMC Res Notes
Springer Science and Business Media LLC
MetadataShow full item record
Petry, C., Ong, K., Hughes, I., Acerini, C., & Dunger, D. (2018). The influence of maternal pregnancy glucose concentrations on associations between a fetal imprinted gene allele score and offspring size at birth.. BMC Res Notes, 11 (1), 821. https://doi.org/10.1186/s13104-018-3933-1
OBJECTIVE: Previously we found that certain fetal imprinted genes represented as an allele score are associated with maternal pregnancy glucose concentrations. Recently it was reported that fetal polymorphisms with strong associations with birth weight tend to mediate these independently of increases in maternal pregnancy glucose concentrations. We therefore investigated whether potential associations between the fetal allele score and birth weight were related to maternal glucose concentrations in the Cambridge Baby Growth Study. RESULTS: The fetal imprinted gene allele score was positively associated with birth weight (β = 63 (17-109) g/risk allele, β' = 0.113, p = 7.6 × 10-3, n = 405). This association was partially attenuated by adjusting for maternal glucose concentrations (β = 50 (4-95) g/risk allele, β' = 0.089, p = 0.03, n = 405). The allele score was also positively associated with risk of being large for gestational age at birth (odds ratio 1.60 (1.19-2.15) per risk allele, p = 2.1 × 10-3, n = 660) and negatively associated with risk of being small for gestational age at birth (odds ratio 0.65 (0.44-0.96) per risk allele, p = 0.03, n = 660). The large for gestational age at birth association was also partially attenuated by maternal glucose concentrations. These results suggest that associations between the fetal imprinted gene allele score and size at birth are mediated through both glucose-dependent and glucose-independent mechanisms.
Humans, Birth Weight, Blood Glucose, Hematologic Tests, Prenatal Care, Odds Ratio, Risk, Longitudinal Studies, Mothers, Genomic Imprinting, Gestational Age, Pregnancy, Genotype, Polymorphism, Genetic, Alleles, Models, Genetic, Adult, Infant, Newborn, Infant, Small for Gestational Age, Female, Male, United Kingdom
This work was supported by the Evelyn Trust (grant number EW9035322); Diabetes U.K. (grant number 11/0004241); the Wellbeing of Women (the Royal College of Obstetricians and Gynaecologists, U.K.) (grant number RG1644); the Medical Research Council (grant numbers G1001995, 7500001180); European Union Framework 5 (grant number QLK4-1999-01422); the Mothercare Charitable Foundation (grant number RG54608); Newlife Foundation for Disabled Children (grant number 07/20); the World Cancer Research Fund International (grant number 2004/03); and the National Institute for Health Research Cambridge Biomedical Research Centre. KO is supported by the Medical Research Council (Unit Programme number: MC_UU_12015/2).
Evelyn Trust (unknown)
National Institute for Health Research (NIHR) (unknown)
Wellbeing of Women (RG1644)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
MRC Epidemiology Unit (7500001180)
Medical Research Council (MC_UU_12015/2)
Medical Research Council (G1001995)
Diabetes UK (DUK-11/0004241)
External DOI: https://doi.org/10.1186/s13104-018-3933-1
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286884
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/