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dc.contributor.authorDe Lucia Rolfe, Emanuella
dc.contributor.authorBrage, Soren
dc.contributor.authorSleigh, Alison
dc.contributor.authorFinucane, Francis
dc.contributor.authorGriffin, Simon J
dc.contributor.authorWareham, Nick J
dc.contributor.authorOng, Ken K
dc.contributor.authorForouhi, Nita G
dc.date.accessioned2018-12-15T00:30:14Z
dc.date.available2018-12-15T00:30:14Z
dc.date.issued2018
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286976
dc.description.abstractBACKGROUND: The rising prevalence of obesity has made hepatic steatosis an increasingly common issue. Ultrasound is generally used in clinical practice to assess steatosis, but its accuracy has been inconsistent across studies. We aimed to determine the validity of ultrasound to diagnose hepatic steatosis when compared to the criterion method proton magnetic resonance spectroscopy (MRS) in older individuals. METHODS: A total of 72 healthy white European individuals (n = 42 men; n = 30 women aged 67-76 years) participating in the Hertfordshire Birth Cohort Physical Activity trial had hepatic steatosis assessed by ultrasound and MRS. The ultrasound scans were graded as normal, mild, moderate and severe steatosis, while hepatic fat content above 5.5% by MRS was used as a cut-off for steatosis. RESULTS: 18 participants (25%) had a level of hepatic fat measured by MRS consistent with diagnosis of steatosis. The sensitivity and specificity of ultrasound in diagnosing hepatic steatosis (mild/moderate/severe vs normal) were 96% (95% CI: 87-99.6%) and 94% (95% CI: 73-100%) respectively, although overlap in MRS hepatic fat content was observed between the ultrasound categories. CONCLUSIONS: Ultrasound is a valid method for detecting the presence or absence of hepatic steatosis in older adults and can be used as an alternative tool in both clinical investigations and epidemiological studies, when other imaging techniques are not feasible.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectLiver
dc.subjectAdipose Tissue
dc.subjectHumans
dc.subjectFatty Liver
dc.subjectObserver Variation
dc.subjectMagnetic Resonance Imaging
dc.subjectUltrasonography
dc.subjectSensitivity and Specificity
dc.subjectRetrospective Studies
dc.subjectAged
dc.subjectFemale
dc.subjectMale
dc.subjectProton Magnetic Resonance Spectroscopy
dc.titleValidity of ultrasonography to assess hepatic steatosis compared to magnetic resonance spectroscopy as a criterion method in older adults.
dc.typeArticle
prism.issueIdentifier11
prism.publicationDate2018
prism.publicationNamePLoS One
prism.startingPagee0207923
prism.volume13
dc.identifier.doi10.17863/CAM.34285
dcterms.dateAccepted2018-11-08
rioxxterms.versionofrecord10.1371/journal.pone.0207923
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidDe Lucia Rolfe, Emanuella [0000-0003-3542-2767]
dc.identifier.eissn1932-6203
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/2)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/5)
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)
pubs.funder-project-idMedical Research Council (MC_UU_12015/4)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0515-10119)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (3360)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
cam.issuedOnline2018-11-26


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International