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dc.contributor.authorZhu, Tianyuen
dc.contributor.authorZheng, Shijie Cen
dc.contributor.authorPaul, Dirken
dc.contributor.authorHorvath, Steveen
dc.contributor.authorTeschendorff, Andrew Een
dc.date.accessioned2018-12-18T00:30:13Z
dc.date.available2018-12-18T00:30:13Z
dc.date.issued2018-11en
dc.identifier.issn1945-4589
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287012
dc.description.abstractAge-associated DNA methylation changes have been widely reported across many different tissue and cell types. Epigenetic ‘clocks’ that can predict chronological age with a surprisingly high degree of accuracy appear to do so independently of tissue and cell-type, suggesting that a component of epigenetic drift is cell-type independent. However, the relative amount of age-associated DNAm changes that are specific to a cell or tissue type versus the amount that occurs independently of cell or tissue type is unclear and a matter of debate, with a recent study concluding that most epigenetic drift is tissue-specific. Here, we perform a novel comprehensive statistical analysis, including matched multi cell-type and multi-tissue DNA methylation profiles from the same individuals and adjusting for cell-type heterogeneity, demonstrating that a substantial amount of epigenetic drift, possibly over 70%, is shared between significant numbers of different tissue/cell types. We further show that ELOVL2 is not unique and that many other CpG sites, some mapping to genes in the Wnt and glutamate receptor signaling pathways, are altered with age 36 across at least 10 different cell/tissue types. We propose that while most age-associated DNAm changes are shared between cell-types that the putative functional effect is likely to be tissue-specific.
dc.format.mediumPrinten
dc.languageengen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCheeken
dc.subjectLiveren
dc.subjectCervix Uterien
dc.subjectBrainen
dc.subjectCD4-Positive T-Lymphocytesen
dc.subjectCD8-Positive T-Lymphocytesen
dc.subjectFibroblastsen
dc.subjectHumansen
dc.subjectDNA Methylationen
dc.subjectEpigenesis, Geneticen
dc.subjectAgingen
dc.subjectFemaleen
dc.subjectMaleen
dc.titleCell and tissue type independent age-associated DNA methylation changes are not rare but common.en
dc.typeArticle
prism.endingPage3557
prism.issueIdentifier11en
prism.publicationDate2018en
prism.publicationNameAgingen
prism.startingPage3541
prism.volume10en
dc.identifier.doi10.17863/CAM.34322
dcterms.dateAccepted2018-11-15en
rioxxterms.versionofrecord10.18632/aging.101666en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-11en
dc.contributor.orcidPaul, Dirk [0000-0002-8230-0116]
dc.identifier.eissn1945-4589
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International