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dc.contributor.authorRhee, Christopher J
dc.contributor.authorda Costa, Cristine Sortica
dc.contributor.authorAustin, Topun
dc.contributor.authorBrady, Ken M
dc.contributor.authorCzosnyka, Marek
dc.contributor.authorLee, Jennifer K
dc.date.accessioned2018-12-18T00:31:10Z
dc.date.available2018-12-18T00:31:10Z
dc.date.issued2018-11
dc.identifier.issn0031-3998
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287047
dc.description.abstractCerebrovascular pressure autoregulation is the physiologic mechanism that holds cerebral blood flow (CBF) relatively constant across changes in cerebral perfusion pressure (CPP). Cerebral vasoreactivity refers to the vasoconstriction and vasodilation that occur during fluctuations in arterial blood pressure (ABP) to maintain autoregulation. These are vital protective mechanisms of the brain. Impairments in pressure autoregulation increase the risk of brain injury and persistent neurologic disability. Autoregulation may be impaired during various neonatal disease states including prematurity, hypoxic-ischemic encephalopathy (HIE), intraventricular hemorrhage, congenital cardiac disease, and infants requiring extracorporeal membrane oxygenation (ECMO). Because infants are exquisitely sensitive to changes in cerebral blood flow (CBF), both hypoperfusion and hyperperfusion can cause significant neurologic injury. We will review neonatal pressure autoregulation and autoregulation monitoring techniques with a focus on brain protection. Current clinical therapies have failed to fully prevent permanent brain injuries in neonates. Adjuvant treatments that support and optimize autoregulation may improve neurologic outcomes.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectHumans
dc.subjectInfant, Newborn, Diseases
dc.subjectSpectroscopy, Near-Infrared
dc.subjectMonitoring, Physiologic
dc.subjectExtracorporeal Membrane Oxygenation
dc.subjectHomeostasis
dc.subjectCerebrovascular Circulation
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectArterial Pressure
dc.titleNeonatal cerebrovascular autoregulation.
dc.typeArticle
prism.endingPage610
prism.issueIdentifier5
prism.publicationDate2018
prism.publicationNamePediatr Res
prism.startingPage602
prism.volume84
dc.identifier.doi10.17863/CAM.34357
dcterms.dateAccepted2018-07-27
rioxxterms.versionofrecord10.1038/s41390-018-0141-6
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11
dc.contributor.orcidAustin, Topun [0000-0002-8428-8624]
dc.contributor.orcidCzosnyka, Marek [0000-0003-2446-8006]
dc.identifier.eissn1530-0447
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-09-08
rioxxterms.freetoread.startdate2019-03-08


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