Show simple item record

dc.contributor.authorO'Connor, Rebecca E
dc.contributor.authorKiazim, Lucas
dc.contributor.authorSkinner, Benjamin
dc.contributor.authorFonseka, Gothami
dc.contributor.authorJoseph, Sunitha
dc.contributor.authorJennings, Rebecca
dc.contributor.authorLarkin, Denis M
dc.contributor.authorGriffin, Darren K
dc.date.accessioned2018-12-18T00:32:05Z
dc.date.available2018-12-18T00:32:05Z
dc.date.issued2019-03
dc.identifier.issn0009-5915
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287081
dc.description.abstractThe structure and organization of a species genome at a karyotypic level, and in interphase nuclei, have broad functional significance. Although regular sized chromosomes are studied extensively in this regard, microchromosomes, which are present in many terrestrial vertebrates, remain poorly explored. Birds have more cytologically indistinguishable microchromosomes (~ 30 pairs) than other vertebrates; however, the degree to which genome organization patterns at a karyotypic and interphase level differ between species is unknown. In species where microchromosomes have fused to other chromosomes, they retain genomic features such as gene density and GC content; however, the extent to which they retain a central nuclear position has not been investigated. In studying 22 avian species from 10 orders, we established that, other than in species where microchromosomal fusion is obvious (Falconiformes and Psittaciformes), there was no evidence of microchromosomal rearrangement, suggesting an evolutionarily stable avian genome (karyotypic) organization. Moreover, in species where microchromosomal fusion has occurred, they retain a central nuclear location, suggesting that the nuclear position of microchromosomes is a function of their genomic features rather than their physical size.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectChromosomes
dc.subjectAnimals
dc.subjectBirds
dc.subjectChromosome Painting
dc.subjectKaryotyping
dc.subjectPhylogeny
dc.subjectSpecies Specificity
dc.subjectRecombination, Genetic
dc.subjectSynteny
dc.subjectGenome
dc.subjectBiological Evolution
dc.titlePatterns of microchromosome organization remain highly conserved throughout avian evolution.
dc.typeArticle
prism.endingPage29
prism.issueIdentifier1
prism.publicationDate2019
prism.publicationNameChromosoma
prism.startingPage21
prism.volume128
dc.identifier.doi10.17863/CAM.34391
dcterms.dateAccepted2018-11-05
rioxxterms.versionofrecord10.1007/s00412-018-0685-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-03
dc.contributor.orcidO'Connor, Rebecca E [0000-0002-4270-970X]
dc.contributor.orcidSkinner, Benjamin [0000-0002-7152-1167]
dc.identifier.eissn1432-0886
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/N000129/1)
cam.issuedOnline2018-11-17


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International