Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Murphy, Michael P
O'Neill, Luke AJ
Abstract
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.
Description
Keywords
Animals, Citric Acid Cycle, Humans, Signal Transduction, Succinates, Succinic Acid
Journal Title
Cell
Conference Name
Journal ISSN
0092-8674
1097-4172
1097-4172
Volume Title
174
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Medical Research Council (MC_UU_00015/3)
Wellcome Trust (110159/Z/15/Z)
Medical Research Council (MC_UU_00015/8)
MRC (MC_UU_00015/8)
Medical Research Council (MC_UU_00015/7)
Wellcome Trust (110159/Z/15/Z)
Medical Research Council (MC_UU_00015/8)
MRC (MC_UU_00015/8)
Medical Research Council (MC_UU_00015/7)