Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.

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Authors
Murphy, Michael P
O'Neill, Luke AJ
Publication Date
2018-08-09
Journal Title
Cell
ISSN
0092-8674
Publisher
Elsevier BV
Volume
174
Issue
4
Pages
780-784
Language
eng
Type
Article
This Version
AM
Physical Medium
Print
Metadata
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Citation
Murphy, M. P., & O'Neill, L. A. (2018). Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.. Cell, 174 (4), 780-784. https://doi.org/10.1016/j.cell.2018.07.030
Abstract
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.
Keywords
Animals, Humans, Succinic Acid, Succinates, Signal Transduction, Citric Acid Cycle
Sponsorship
Medical Research Council (MC_UU_00015/3)
Wellcome Trust (110159/Z/15/Z)
Medical Research Council (MC_UU_00015/8)
MRC (MC_UU_00015/8)
Identifiers
External DOI: https://doi.org/10.1016/j.cell.2018.07.030
This record's URL: https://www.repository.cam.ac.uk/handle/1810/287097
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International