Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.

Murphy, Mike; O'Neill, Luke AJ

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Authors

Murphy, Mike

O'Neill, Luke AJ

Publication Date

2018-08-09

Journal Title

Cell

ISSN

0092-8674

Publisher

Elsevier BV

Volume

174

Issue

Pages

780-784

Language

eng

Type

Article

This Version

Physical Medium

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Citation

Murphy, M., & O'Neill, L. A. (2018). Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.. Cell, 174 (4), 780-784. https://doi.org/10.1016/j.cell.2018.07.030

Abstract

Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.

Keywords

Animals, Humans, Succinic Acid, Succinates, Signal Transduction, Citric Acid Cycle

Sponsorship

Medical Research Council (MC_UU_00015/3)

Wellcome Trust (110159/Z/15/Z)

Medical Research Council (MC_UU_00015/8)

MRC (MC_UU_00015/8)

Identifiers

External DOI: https://doi.org/10.1016/j.cell.2018.07.030

This record's URL: https://www.repository.cam.ac.uk/handle/1810/287097

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International

Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/

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