Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.
Murphy, Michael P
O'Neill, Luke AJ
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Murphy, M. P., & O'Neill, L. A. (2018). Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.. Cell, 174 (4), 780-784. https://doi.org/10.1016/j.cell.2018.07.030
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.
Animals, Humans, Succinic Acid, Succinates, Signal Transduction, Citric Acid Cycle
Medical Research Council (MC_UU_00015/3)
Wellcome Trust (110159/Z/15/Z)
Medical Research Council (MC_UU_00015/8)
External DOI: https://doi.org/10.1016/j.cell.2018.07.030
This record's URL: https://www.repository.cam.ac.uk/handle/1810/287097
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/