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dc.contributor.authorEaston, Douglasen
dc.contributor.authorThompson, Deborahen
dc.date.accessioned2018-12-18T10:00:00Z
dc.date.available2018-12-18T10:00:00Z
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287134
dc.description.abstractEndometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS) we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5,624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes and risk alleles at two of these loci that associate with decreased expression of genes which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleIdentification of nine new susceptibility loci for endometrial canceren
dc.typeArticle
prism.number3166en
prism.publicationNameNature Communicationsen
prism.volume9en
dc.identifier.doi10.17863/CAM.34441
dcterms.dateAccepted2018-07-02en
rioxxterms.versionofrecord10.1038/s41467-018-05427-7en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-07-02en
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.contributor.orcidThompson, Deborah [0000-0003-1465-5799]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (16565)
pubs.funder-project-idMRC (MC_UU_12015/2)
pubs.funder-project-idNational Cancer Institute (NCI) (U19CA148537)
pubs.funder-project-idNational Cancer Institute (NCI) (R01CA128978)
pubs.funder-project-idNational Cancer Institute (NCI) (U19CA148065)
pubs.funder-project-idEC FP7 CP (223175)
pubs.funder-project-idNational Health and Medical Research Council (1109286)
pubs.funder-project-idCancer Research UK (CRUK-A10710)
pubs.funder-project-idCancer Research UK (CRUK-A12014)
pubs.funder-project-idCancer Research UK (CRUK-A10118)
pubs.funder-project-idNational Health and Medical Research Council (1109286)
pubs.funder-project-idNational Health and Medical Research Council (1031333)
cam.issuedOnline2018-08-09en
dc.identifier.urlhttps://www.nature.com/articles/s41467-018-05427-7#article-infoen


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Except where otherwise noted, this item's licence is described as Attribution 4.0 International