Show simple item record

dc.contributor.authorLiu, Kathy Yen
dc.contributor.authorAcosta-Cabronero, Julioen
dc.contributor.authorCardenas-Blanco, Arturoen
dc.contributor.authorLoane, Clareen
dc.contributor.authorBerry, Alex Jen
dc.contributor.authorBetts, Matthew Jen
dc.contributor.authorKievit, Rogieren
dc.contributor.authorHenson, Riken
dc.contributor.authorDüzel, Emrahen
dc.contributor.authorCam-CAN,en
dc.contributor.authorHoward, Roberten
dc.contributor.authorHämmerer, Dorotheaen
dc.date.accessioned2018-12-19T00:30:21Z
dc.date.available2018-12-19T00:30:21Z
dc.date.issued2019-02en
dc.identifier.issn0197-4580
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287152
dc.description.abstractThe locus coeruleus (LC), the major origin of noradrenergic modulation of the central nervous system, may play an important role in neuropsychiatric disorders including Parkinson's disease and Alzheimer's disease. The pattern of age-related change of the LC across the life span is unclear. We obtained normalized, mean LC signal intensity values, that is, contrast ratios (CRs), from magnetization transfer-weighted images to investigate the relationship between LC CR and age in cognitively normal healthy adults (N = 605, age range 18-88 years). Study participants were part of the Cambridge Centre for Ageing and Neuroscience-an open-access, population-based data set. We found a quadratic relationship between LC CR and age, the peak occurring around 60 years, with no differences between males and females. Subregional analyses revealed that age-related decline in LC CR was confined to the rostral portion of the LC. Older adults showed greater variance in overall LC CR than younger adults, and the functional and clinical implications of these observed age-related differences require further investigation. Visualization of the LC in this study may inform how future scanning parameters can be optimized, and provides insight into how LC integrity changes across the life span.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCam-CANen
dc.subjectLocus Coeruleusen
dc.subjectHumansen
dc.subjectMelaninsen
dc.subjectMagnetic Resonance Imagingen
dc.subjectCognitionen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectYoung Adulten
dc.subjectHealthy Agingen
dc.titleIn vivo visualization of age-related differences in the locus coeruleus.en
dc.typeArticle
prism.endingPage111
prism.publicationDate2019en
prism.publicationNameNeurobiology of agingen
prism.startingPage101
prism.volume74en
dc.identifier.doi10.17863/CAM.34461
dcterms.dateAccepted2018-10-11en
rioxxterms.versionofrecord10.1016/j.neurobiolaging.2018.10.014en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-02en
dc.contributor.orcidAcosta-Cabronero, Julio [0000-0003-1174-5983]
dc.contributor.orcidBerry, Alex J [0000-0001-6231-541X]
dc.contributor.orcidBetts, Matthew J [0000-0002-2840-4678]
dc.contributor.orcidKievit, Rogier [0000-0003-0700-4568]
dc.contributor.orcidHenson, Richard [0000-0002-0712-2639]
dc.contributor.orcidDüzel, Emrah [0000-0002-0139-5388]
dc.identifier.eissn1558-1497
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) ERC (732592)
pubs.funder-project-idMRC (Unknown)
pubs.funder-project-idBBSRC (BB/H008217/1)
pubs.funder-project-idMedical Research Council (MC_UU_00005/8)
pubs.funder-project-idMedical Research Council (MC_UP_1401/1)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International