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dc.contributor.authorTastekin, Ibrahim
dc.contributor.authorKhandelwal, Avinash
dc.contributor.authorTadres, David
dc.contributor.authorFessner, Nico D
dc.contributor.authorTruman, James W
dc.contributor.authorZlatic, Marta
dc.contributor.authorCardona, Albert
dc.contributor.authorLouis, Matthieu
dc.date.accessioned2018-12-20T00:30:52Z
dc.date.available2018-12-20T00:30:52Z
dc.date.issued2018-11-22
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287225
dc.description.abstractSensory navigation results from coordinated transitions between distinct behavioral programs. During chemotaxis in the Drosophila melanogaster larva, the detection of positive odor gradients extends runs while negative gradients promote stops and turns. This algorithm represents a foundation for the control of sensory navigation across phyla. In the present work, we identified an olfactory descending neuron, PDM-DN, which plays a pivotal role in the organization of stops and turns in response to the detection of graded changes in odor concentrations. Artificial activation of this descending neuron induces deterministic stops followed by the initiation of turning maneuvers through head casts. Using electron microscopy, we reconstructed the main pathway that connects the PDM-DN neuron to the peripheral olfactory system and to the pre-motor circuit responsible for the actuation of forward peristalsis. Our results set the stage for a detailed mechanistic analysis of the sensorimotor conversion of graded olfactory inputs into action selection to perform goal-oriented navigation.
dc.format.mediumElectronic
dc.languageeng
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectOlfactory Receptor Neurons
dc.subjectMotor Neurons
dc.subjectAnimals
dc.subjectDrosophila melanogaster
dc.subjectBiological Assay
dc.subjectBehavior, Animal
dc.subjectMotor Activity
dc.subjectSmell
dc.subjectChemotaxis
dc.subjectLarva
dc.subjectPeristalsis
dc.subjectLocomotion
dc.subjectPhenotype
dc.subjectGenetic Testing
dc.subjectOptogenetics
dc.subjectSensorimotor Cortex
dc.titleSensorimotor pathway controlling stopping behavior during chemotaxis in the Drosophila melanogaster larva.
dc.typeArticle
prism.publicationDate2018
prism.publicationNameElife
prism.volume7
dc.identifier.doi10.17863/CAM.34532
dcterms.dateAccepted2018-11-07
rioxxterms.versionofrecord10.7554/eLife.38740
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11-22
dc.contributor.orcidTastekin, Ibrahim [0000-0003-3661-9115]
dc.contributor.orcidTadres, David [0000-0002-7570-0162]
dc.contributor.orcidTruman, James W [0000-0002-9209-5435]
dc.contributor.orcidZlatic, Marta [0000-0002-3149-2250]
dc.contributor.orcidCardona, Albert [0000-0003-4941-6536]
dc.contributor.orcidLouis, Matthieu [0000-0002-2267-0262]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-11-22


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International