Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Chen, Yiding
Leonardi, Marco
Dingwall, Paul
Labes, Ricardo https://orcid.org/0000-0003-4001-0775
Pasau, Patrick https://orcid.org/0000-0002-1777-7911
Abstract
Cheap and readily available aqueous formaldehyde was used as a formylating reagent in a homologation reaction with nonstabilized diazo compounds, enabled by UV photolysis of bench-stable oxadiazolines in a flow photoreactor. Various aliphatic aldehydes were synthesized along with the corresponding derivatized alcohols and benzimidazoles. No transition-metal catalyst or additive was required to affect the reaction, which proceeded at room temperature in 80 min.
Description
Keywords
0306 Physical Chemistry (incl. Structural)
Journal Title
J Org Chem
Conference Name
Journal ISSN
0022-3263
1520-6904
1520-6904
Volume Title
83
Publisher
American Chemical Society (ACS)
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)
Engineering and Physical Sciences Research Council (EP/K039520/1)