Large-Scale Synthesis of Crystalline 1,2,3,4,6,7-Hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Stanetty, Christian
Baxendale, Ian R https://orcid.org/0000-0003-1297-1552
Abstract
The higher-carbon sugar l-glycero-d-manno-heptose is a major constituent of the inner core region of the lipopolysaccharide (LPS) of many Gram-negative bacteria. All preparative routes used to date require multiple steps, and scalability has been rarely addressed. Here a highly practical synthesis of crystalline 1,2,3,4,6,7-hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose by a simple four-step sequence starting from l-lyxose is disclosed. Only two recrystallisations are required and the process was demonstrated on a >100 mmol scale, yielding 41 g of the target compound.
Description
Keywords
Allylation, Carbohydrates, Indium, Rare sugars, Synthetic methods
Journal Title
European J Org Chem
Conference Name
Journal ISSN
1434-193X
1099-0690
1099-0690
Volume Title
2015
Publisher
Wiley