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dc.contributor.authorAllison, Annabel
dc.contributor.authorWhite, Ian R
dc.contributor.authorBond, Simon
dc.date.accessioned2018-12-20T00:31:21Z
dc.date.available2018-12-20T00:31:21Z
dc.date.issued2017-12-04
dc.identifier.issn2073-4859
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287242
dc.description.abstractTreatment switching in a randomised controlled trial occurs when participants change from their randomised treatment to the other trial treatment during the study. Failure to account for treatment switching in the analysis (i.e. by performing a standard intention-to-treat analysis) can lead to biased estimates of treatment efficacy. The rank preserving structural failure time model (RPSFTM) is a method used to adjust for treatment switching in trials with survival outcomes. The RPSFTM is due to Robins and Tsiatis (1991) and has been developed by White et al. (1997, 1999). The method is randomisation based and uses only the randomised treatment group, observed event times, and treatment history in order to estimate a causal treatment effect. The treatment effect, ψ, is estimated by balancing counter-factual event times (that would be observed if no treatment were received) between treatment groups. G-estimation is used to find the value of ψ such that a test statistic Z(ψ) = 0. This is usually the test statistic used in the intention-to-treat analysis, for example, the log rank test statistic. We present an R package that implements the method of rpsftm.
dc.format.mediumPrint
dc.languageeng
dc.publisherThe R Foundation
dc.titlerpsftm: An R Package for Rank Preserving Structural Failure Time Models.
dc.typeArticle
prism.endingPage353
prism.issueIdentifier2
prism.publicationDate2017
prism.publicationNameR J
prism.startingPage342
prism.volume9
dc.identifier.doi10.17863/CAM.34549
rioxxterms.versionofrecord10.32614/rj-2017-068
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-12
dc.contributor.orcidAllison, Annabel [0000-0002-9122-6341]
dc.contributor.orcidBond, Simon [0000-0003-2528-1040]
dc.identifier.eissn2073-4859
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017
rioxxterms.freetoread.startdate2018-12-31


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