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dc.contributor.authorDalley, Jeffrey W
dc.contributor.authorErsche, Karen D
dc.date.accessioned2018-12-20T00:31:47Z
dc.date.available2018-12-20T00:31:47Z
dc.date.issued2019-02-18
dc.identifier.issn0962-8436
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287257
dc.description.abstractImpatience-the failure to wait or tolerate delayed rewards (e.g. food, drug and monetary incentives)-is a common behavioural tendency in humans. However, when rigidly and rapidly expressed with limited regard for future, often negative consequences, impatient or impulsive actions underlie and confer susceptibility for such diverse brain disorders as drug addiction, attention-deficit hyperactivity disorder (ADHD) and major depressive disorder. Consequently, 'waiting' impulsivity has emerged as a candidate endophenotype to inform translational research on underlying neurobiological mechanisms and biomarker discovery for many of the so-called impulse-control disorders. Indeed, as reviewed in this article, this research enterprise has revealed a number of unexpected targets and mechanisms for intervention. However, in the context of drug addiction, impulsive decisions that maximize short-term gains (e.g. acute drug consumption) over longer-term punishment (e.g. unemployment, homelessness, personal harm) defines one aspect of impulsivity, which may or may not be related to rapid, unrestrained actions over shorter timescales. We discuss the relevance of this distinction in impulsivity subtypes for drug addiction with reference to translational research in humans and other animals. This article is part of the theme issue 'Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications'.
dc.description.sponsorshipBritish Academy; NIHR Cambridge Biomedical Research Centre
dc.format.mediumPrint
dc.languageeng
dc.publisherThe Royal Society
dc.subjectHumans
dc.subjectSubstance-Related Disorders
dc.subjectImpulsive Behavior
dc.subjectPunishment
dc.subjectReward
dc.subjectTranslational Medical Research
dc.titleNeural circuitry and mechanisms of waiting impulsivity: relevance to addiction.
dc.typeArticle
prism.issueIdentifier1766
prism.publicationDate2019
prism.publicationNamePhilos Trans R Soc Lond B Biol Sci
prism.startingPage20180145
prism.volume374
dc.identifier.doi10.17863/CAM.34564
dcterms.dateAccepted2018-12-05
rioxxterms.versionofrecord10.1098/rstb.2018.0145
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-02
dc.contributor.orcidDalley, Jeffrey [0000-0002-2282-3660]
dc.contributor.orcidErsche, Karen [0000-0002-3203-1878]
dc.identifier.eissn1471-2970
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G0701500)
pubs.funder-project-idImperial College London (11/H0707/9)
pubs.funder-project-idMedical Research Council (MR/N02530X/1)
pubs.funder-project-idMedical Research Council (G1002231)
pubs.funder-project-idMedical Research Council (G0802729)
cam.issuedOnline2018-12-31
rioxxterms.freetoread.startdate2019-12-31


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