Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.

Pinho, Brígida R; Reis, Sara D; Hartley, Richard C; Murphy, Mike; Oliveira, Jorge MA

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Authors

Pinho, Brígida R

Reis, Sara D

Hartley, Richard C

Murphy, Mike

Oliveira, Jorge MA

Publication Date

2019-01

Journal Title

Free radical biology & medicine

ISSN

0891-5849

Volume

130

Pages

318-327

Language

eng

Type

Article

This Version

Physical Medium

Print-Electronic

Metadata

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Citation

Pinho, B. R., Reis, S. D., Hartley, R. C., Murphy, M., & Oliveira, J. M. (2019). Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.. Free radical biology & medicine, 130 318-327. https://doi.org/10.1016/j.freeradbiomed.2018.10.446

Keywords

Brain, Mitochondria, Animals, Zebrafish, Humans, Huntington Disease, Parkinson Disease, Superoxides, Reactive Oxygen Species, Paraquat, Rotenone, Tyrosine 3-Monooxygenase, Antioxidants, Oxidation-Reduction, Oxidative Stress, Phenotype, Protein Aggregation, Pathological, Huntingtin Protein

Sponsorship

MRC (MC_UU_00015/3)

Wellcome Trust (110159/Z/15/Z)

MRC (MC_U105663142)

Identifiers

External DOI: https://doi.org/10.1016/j.freeradbiomed.2018.10.446

This record's URL: https://www.repository.cam.ac.uk/handle/1810/287280

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International

Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/

The following licence files are associated with this item:

Creative Commons

Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International