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dc.contributor.authorPerez Moreno, Juanen
dc.contributor.authorO'Kane, Cahiren
dc.date.accessioned2018-12-21T00:31:55Z
dc.date.available2018-12-21T00:31:55Z
dc.date.issued2019-02-07en
dc.identifier.issn2160-1836
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287337
dc.description.abstractThe Drosophila melanogaster larval neuromuscular system is extensively used by researchers to study neuronal cell biology, and Drosophila glutamatergic motor neurons have become a major model system. There are two main Types of glutamatergic motor neurons, Ib and Is, with different structural and physiological properties at synaptic level at the neuromuscular junction. To generate genetic tools to identify and manipulate motor neurons of each Type, we screened for GAL4 driver lines for this purpose. Here we describe GAL4 drivers specific for examples of neurons within each Type, Ib or Is. These drivers showed high expression levels and were expressed in only few motor neurons, making them amenable tools for specific studies of both axonal and synapse biology in identified Type I motor neurons.
dc.description.sponsorshipThis work was supported by grant BB/L021706/1 from the UK Biotechnology and Biological Sciences Research Council to CJO’K, and Marie Sklodowska-Curie 19 fellowship 745007 from the European Union Horizon 2020 research and innovation programme to JJPM.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherGenetics Society of America
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMotor Neuronsen
dc.subjectNeuromuscular Junctionen
dc.subjectAnimalsen
dc.subjectDrosophila melanogasteren
dc.subjectGlutamic Aciden
dc.subjectDrosophila Proteinsen
dc.subjectGreen Fluorescent Proteinsen
dc.subjectTranscription Factorsen
dc.title<i>GAL4</i> Drivers Specific for Type Ib and Type Is Motor Neurons in <i>Drosophila</i>.en
dc.typeArticle
prism.endingPage462
prism.issueIdentifier2en
prism.publicationDate2019en
prism.publicationNameG3 (Bethesda, Md.)en
prism.startingPage453
prism.volume9en
dc.identifier.doi10.17863/CAM.34641
dcterms.dateAccepted2018-12-07en
rioxxterms.versionofrecord10.1534/g3.118.200809en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-02-07en
dc.contributor.orcidPérez-Moreno, Juan [0000-0002-8497-3066]
dc.contributor.orcidO'Kane, Charles [0000-0002-3488-2078]
dc.identifier.eissn2160-1836
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/L021706/1)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (745007)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International