Show simple item record

dc.contributor.authorLawrence, Peter
dc.contributor.authorCasal Jimenez, Jose
dc.date.accessioned2018-12-22T00:30:39Z
dc.date.available2018-12-22T00:30:39Z
dc.date.issued2018-12-10
dc.identifier.issn0950-1991
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287374
dc.description.abstractOur aim in this short Primer is to explain the principles of planar cell polarity (PCP) in animal development. The literature in this small field is complex and specialized, but we have extracted a simple and central story from it. We explain our hypothesis that polarity, initially cued by the direction of slope of a multicellular gradient, is interpreted at the cellular level so that each cell becomes molecularly polarised. The mechanism involves a comparison between a cell and its neighbours. To achieve this comparison there are (at least) two disparate and independent molecular systems, each depending on molecular bridges that span between neighbouring cells. Even though the two systems are made up of different molecules, we argue that both systems function in a logically equivalent way.
dc.description.sponsorshipWellcome Trust (WT107060MA)
dc.format.mediumElectronic
dc.languageeng
dc.publisherThe Company of Biologists
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCell Membrane
dc.subjectAnimals
dc.subjectSignal Transduction
dc.subjectCell Polarity
dc.subjectModels, Biological
dc.titlePlanar cell polarity: two genetic systems use one mechanism to read gradients.
dc.typeArticle
prism.issueIdentifier23
prism.publicationDate2018
prism.publicationNameDevelopment
prism.volume145
dc.identifier.doi10.17863/CAM.34678
dcterms.dateAccepted2018-11-01
rioxxterms.versionofrecord10.1242/dev.168229
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-12-10
dc.contributor.orcidLawrence, Peter [0000-0002-9554-8268]
dc.contributor.orcidCasal Jimenez, Jose [0000-0002-5149-1335]
dc.identifier.eissn1477-9129
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (107060/Z/15/Z)
pubs.funder-project-idWellcome Trust (096645/Z/11/Z)
cam.issuedOnline2018-12-10
rioxxterms.freetoread.startdate2019-12-21


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International