Evaluation of inert gas rebreathing for determination of cardiac output: influence of age, gender and body size.
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Authors
Middlemiss, Jessica E
Cocks, Alex
Paapstel, Kaido
Sunita, Sunita
ACCT Study Investigators
Publication Date
2019-06Journal Title
Hypertens Res
ISSN
0916-9636
Publisher
Springer Science and Business Media LLC
Volume
42
Issue
6
Pages
834-844
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Middlemiss, J. E., Cocks, A., Paapstel, K., Maki-Petaja, K., Sunita, S., Wilkinson, I., McEniery, C., & et al. (2019). Evaluation of inert gas rebreathing for determination of cardiac output: influence of age, gender and body size.. Hypertens Res, 42 (6), 834-844. https://doi.org/10.1038/s41440-018-0179-1
Abstract
The aim of this study was to evaluate an inert gas rebreathing method (Innocor) for measurement of cardiac output and related haemodynamic variables and to provide robust normative data describing the influence of age, gender and body size on these variables. Four separate studies were conducted: measurement repeatability (study 1, n = 45); postural change (study 2, n = 40); response to submaximal cycling exercise (study 3, n = 20); and the influence of age, gender and body size (study 4, n = 1400). Repeated measurements of cardiac output, stroke volume and heart rate were similar, with low mean (±SD) differences (0.26 ± 0.53 L/min, 0 ± 11 mL and 2 ± 6beats/min, respectively). In addition, cardiac output and stroke volume both declined progressively from supine to seated and standing positions (P < 0.001 for both) and there was a stepwise increase in both parameters moving from rest to submaximal exercise (P < 0.001 for both). In study 4, there was a significant age-related decline in cardiac output and stroke volume in males and females, which remained significant after adjusting for body surface area (BSA, P < 0.001 for all comparisons). Both parameters were also significantly higher in those with high body mass index (BMI; P < 0.01 versus those with normal BMI for all comparisons), although indexing cardiac output and stroke volume to BSA reversed these trends. Inert gas rebreathing using the Innocor device provides repeatable measurements of cardiac output and related indices, which are sensitive to the effects of acute physiological manoeuvres. Moreover, inert gas rebreathing is a suitable technique for examining chronic influences such as age, gender and body size on key haemodynamic components of the arterial blood pressure.
Keywords
ACCT Study Investigators, Humans, Noble Gases, Cardiac Output, Stroke Volume, Body Size, Body Surface Area, Reproducibility of Results, Aging, Sex Characteristics, Heart Rate, Posture, Supine Position, Reference Values, Bicycling, Adult, Middle Aged, Female, Male, Young Adult, Sitting Position, Standing Position
Sponsorship
British Heart Foundation (None)
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation (None)
Identifiers
External DOI: https://doi.org/10.1038/s41440-018-0179-1
This record's URL: https://www.repository.cam.ac.uk/handle/1810/287377
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