Association between CT-texture-derived tumor heterogeneity, outcomes, and BRCA mutation status in patients with high-grade serous ovarian cancer.
Soslow, Robert A
Sutton, Elizabeth J
Vargas, Hebert A
Abdom Radiol (NY)
Springer Science and Business Media LLC
MetadataShow full item record
Meier, A., Veeraraghavan, H., Nougaret, S., Lakhman, Y., Sosa, R., Soslow, R. A., Sutton, E. J., et al. (2019). Association between CT-texture-derived tumor heterogeneity, outcomes, and BRCA mutation status in patients with high-grade serous ovarian cancer.. Abdom Radiol (NY), 44 (6), 2040-2047. https://doi.org/10.1007/s00261-018-1840-5
PURPOSE: To assess the associations between inter-site texture heterogeneity parameters derived from computed tomography (CT), survival, and BRCA mutation status in women with high-grade serous ovarian cancer (HGSOC). MATERIALS AND METHODS: Retrospective study of 88 HGSOC patients undergoing CT and BRCA mutation status testing prior to primary cytoreductive surgery. Associations between texture metrics-namely inter-site cluster variance (SCV), inter-site cluster prominence (SCP), inter-site cluster entropy (SE)-and overall survival (OS), progression-free survival (PFS) as well as BRCA mutation status were assessed. RESULTS: Higher inter-site cluster variance (SCV) was associated with lower PFS (p = 0.006) and OS (p = 0.003). Higher inter-site cluster prominence (SCP) was associated with lower PFS (p = 0.02) and higher inter-site cluster entropy (SE) correlated with lower OS (p = 0.01). Higher values of all three metrics were significantly associated with lower complete surgical resection status in BRCA-negative patients (SE p = 0.039, SCV p = 0.006, SCP p = 0.02), but not in BRCA-positive patients (SE p = 0.7, SCV p = 0.91, SCP p = 0.67). None of the metrics were able to distinguish between BRCA mutation carrier and non-mutation carrier. CONCLUSION: The assessment of tumoral heterogeneity in the era of personalized medicine is important, as increased heterogeneity has been associated with distinct genomic abnormalities and worse patient outcomes. A radiomics approach using standard-of-care CT scans might have a clinical impact by offering a non-invasive tool to predict outcome and therefore improving treatment effectiveness. However, it was not able to assess BRCA mutation status in women with HGSOC.
Humans, Cystadenocarcinoma, Serous, Ovarian Neoplasms, Ubiquitin-Protein Ligases, Radiographic Image Interpretation, Computer-Assisted, Tomography, X-Ray Computed, Retrospective Studies, Mutation, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Neoplasm Grading
External DOI: https://doi.org/10.1007/s00261-018-1840-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/287498