Association between CT-texture-derived tumor heterogeneity, outcomes, and BRCA mutation status in patients with high-grade serous ovarian cancer.
Soslow, Robert A
Vargas, Hebert A
Abdominal radiology (New York)
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Meier, A., Veeraraghavan, H., Nougaret, S., Lakhman, Y., Sosa, R., Soslow, R. A., Sutton, E. J., et al. (2019). Association between CT-texture-derived tumor heterogeneity, outcomes, and BRCA mutation status in patients with high-grade serous ovarian cancer.. Abdominal radiology (New York), 44 (6), 2040-2047. https://doi.org/10.1007/s00261-018-1840-5
PURPOSE: To assess the associations between inter-site texture heterogeneity parameters derived from computed tomography (CT), survival, and BRCA mutation status in women with high-grade serous ovarian cancer (HGSOC). MATERIALS AND METHODS: Retrospective study of 88 HGSOC patients undergoing CT and BRCA mutation status testing prior to primary cytoreductive surgery. Associations between texture metrics-namely inter-site cluster variance (SCV), inter-site cluster prominence (SCP), inter-site cluster entropy (SE)-and overall survival (OS), progression-free survival (PFS) as well as BRCA mutation status were assessed. RESULTS: Higher inter-site cluster variance (SCV) was associated with lower PFS (p = 0.006) and OS (p = 0.003). Higher inter-site cluster prominence (SCP) was associated with lower PFS (p = 0.02) and higher inter-site cluster entropy (SE) correlated with lower OS (p = 0.01). Higher values of all three metrics were significantly associated with lower complete surgical resection status in BRCA-negative patients (SE p = 0.039, SCV p = 0.006, SCP p = 0.02), but not in BRCA-positive patients (SE p = 0.7, SCV p = 0.91, SCP p = 0.67). None of the metrics were able to distinguish between BRCA mutation carrier and non-mutation carrier. CONCLUSION: The assessment of tumoral heterogeneity in the era of personalized medicine is important, as increased heterogeneity has been associated with distinct genomic abnormalities and worse patient outcomes. A radiomics approach using standard-of-care CT scans might have a clinical impact by offering a non-invasive tool to predict outcome and therefore improving treatment effectiveness. However, it was not able to assess BRCA mutation status in women with HGSOC.
Humans, Cystadenocarcinoma, Serous, Ovarian Neoplasms, Ubiquitin-Protein Ligases, Radiographic Image Interpretation, Computer-Assisted, Tomography, X-Ray Computed, Retrospective Studies, Mutation, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Neoplasm Grading
External DOI: https://doi.org/10.1007/s00261-018-1840-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/287498