The Dietary Total-Fat Content Affects the <em>In Vivo</em> Circulating C15:0 and C17:0 Fatty Acid Concentrations Independently to the Dietary Fatty Acid Compositions; Highlighting Dietary Routes that may Attenuate the Development of Metabolic Disease
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Jenkins, B., Aoun, M., Feillet-Coudray, C., Coudray, C., Ronis, M., & Koulman, A. (2018). The Dietary Total-Fat Content Affects the <em>In Vivo</em> Circulating C15:0 and C17:0 Fatty Acid Concentrations Independently to the Dietary Fatty Acid Compositions; Highlighting Dietary Routes that may Attenuate the Development of Metabolic Disease. [Webpages]. https://doi.org/10.20944/preprints201809.0271.v1
Pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) have been described as dietary biomarkers of dairy-fat consumption with varying degrees of reliability between studies. It remains unclear how the total amount of dietary fat; one of the main confounding factors in these biomarker investigations, affects C15:0 and C17:0 circulating compositions independently to their relative intake. Additionally, it is unknown how changes in the dietary total-fat affects other fatty acids in circulation. Through two dietary studies with different total-fat levels but maintaining individual fatty acid compositions we were able to see how the dietary total-fat affects the fatty acids in circulation. We saw that there was a significant, proportionate, and robust decrease in the endogenous C15:0 levels with an increase in dietary total-fat. However, there was an increase in the circulating C17:0 compositions as the total-fat increased. To conclude, the dietary total-fat content and fat-type have a very complex influence on the relative compositions of circulating fatty acids, which are independent to the actual dietary fatty acid composition. Knowing how to manipulate circulating C15:0 and C17:0 composition is far-reaching in nutritional/pathological research as they highlight a dietary route to attenuate the development of metabolic disease (both by reducing risk and improving prognosis).
External DOI: https://doi.org/10.20944/preprints201809.0271.v1
This record's DOI: https://doi.org/10.17863/CAM.34941
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/