SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

Tzelepis, Konstantinos; De Braekeleer, Etienne; Aspris, Demetrios; Barbieri, Isaia; Vijayabaskar, MS; Liu, Wen-Hsin; Gozdecka, Malgorzata; Metzakopian, Emmanouil; Toop, Hamish D; Dudek, Monika; Robson, Samuel C; Hermida-Prado, Francisco; Yang, Yu Hsuen; Babaei-Jadidi, Roya; Garyfallos, Dimitrios A; Ponstingl, Hannes; Dias, Joao ML; Gallipoli, Paolo; Seiler, Michael; Buonamici, Silvia; Vick, Binje; Bannister, Andrew; Rad, Roland; Prinjha, Rab K; Marioni, John; Huntly, Brian; Batson, Jennifer; Morris, Jonathan C; Correia Antunes Pina, Cristina Pina; Bradley, Allan; Jeremias, Irmela; Bates, David O; Yusa, Kosuke; Kouzarides, Tony; Vassiliou, George

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Authors

Tzelepis, Konstantinos

De Braekeleer, Etienne

Aspris, Demetrios

Barbieri, Isaia

Vijayabaskar, MS

Liu, Wen-Hsin

Gozdecka, Malgorzata

Publication Date

2018-12-19

Journal Title

Nature communications

ISSN

2041-1723

Volume

Issue

Pages

5378

Language

eng

Type

Article

This Version

VoR

Physical Medium

Electronic

Metadata

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Citation

Tzelepis, K., De Braekeleer, E., Aspris, D., Barbieri, I., Vijayabaskar, M., Liu, W., Gozdecka, M., et al. (2018). SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.. Nature communications, 9 (1), 5378. https://doi.org/10.1038/s41467-018-07620-0

Keywords

HL-60 Cells, K562 Cells, Chromatin, Humans, Protein-Serine-Threonine Kinases, Cell Cycle Proteins, Nuclear Proteins, Protein Isoforms, Transcription Factors, Cell Differentiation, Hematopoiesis, Epigenesis, Genetic, RNA Splicing, Leukemia, Myeloid, Acute, Cell Cycle Checkpoints

Sponsorship

Leukemia & Lymphoma Society (7001-12)

Kay Kendall Leukaemia Fund (KKL888)

MRC (MC_PC_12009)

WELLCOME TRUST (109967/Z/15/Z)

Medical Research Council (MR/M010392/1)

MRC (MR/R009708/1)

European Research Council (268569)

Wellcome Trust (092096/Z/10/Z)

Cancer Research UK (A14492)

Cancer Research UK (23015)

Identifiers

External DOI: https://doi.org/10.1038/s41467-018-07620-0

This record's URL: https://www.repository.cam.ac.uk/handle/1810/287707

Rights

Attribution 4.0 International

Licence URL: https://creativecommons.org/licenses/by/4.0/

Except where otherwise noted, this item's licence is described as Attribution 4.0 International