Recyclable supported Pd-NHC catalytic systems for the copper free Sonogashira cross-coupling in flow

Authors
Penafiel, Itziar 
Martinez-Lombardia, A 
Godard, C 
Claver, Carmen 
Lapkin, AA 

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Type
Article
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Abstract

A new family of well-defined NHC-Pd complexes immobilised onto silica, alumina and titania is reported. The catalysts display activity and recyclability in the Sonogashira cross-coupling reactions under batch and continuous flow conditions. Under batch conditions the new catalytic systems were recycled up to four times with yields over 80%. These catalysts have a broad substrate scope of different aryl bromides and alkynes. The titania-supported catalysts show good conversions under continuous flow conditions at least over 8 hours on stream using MeOH as solvent.

Publication Date
2018-09-01
Online Publication Date
2018-07-06
Acceptance Date
2018-06-27
Keywords
3402 Inorganic Chemistry, 34 Chemical Sciences
Journal Title
Sustainable Chemistry and Pharmacy
Journal ISSN
2352-5541
Volume Title
9
Publisher
Elsevier
Sponsorship
Centre Tecnol�gic de la Qu�mica de Catalunya (CTQC)
The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (EC FP7) Grant Agreement n. [NMP2-SL-2012-280827]. The authors are grateful to TECSPR14-1-0045; TECNIOspring programme, the Agency for Business Competitiveness of the Government of Catalonia, ACCIÓ, the Generalitat de Catalunya (2014SGR670). and the Spanish Ministerio de Economía y Competitividad (CTQ2016-75016-R) for financial support.