Molecular control of local translation in axon development and maintenance.
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Authors
Holt, CE
Publication Date
2018-08Journal Title
Current Opinion in Neurobiology
ISSN
1873-6882
Publisher
Elsevier
Volume
51
Pages
86-94
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Holt, C. (2018). Molecular control of local translation in axon development and maintenance.. Current Opinion in Neurobiology, 51 86-94. https://doi.org/10.1016/j.conb.2018.02.025
Abstract
The tips of axons are often far away from the cell soma where most proteins are synthesized. Recent work has revealed that axonal mRNA transport and localised translation are key regulatory mechanisms that allow these distant outposts of the cell to respond rapidly to extrinsic factors and maintain axonal homeostasis. Here, we review recent evidence pointing to an increasingly broad role for local protein synthesis in controlling axon shape, synaptogenesis and axon survival by regulating diverse cellular processes such as vesicle trafficking, cytoskeletal remodelling and mitochondrial integrity. We further highlight current research on the regulatory mechanisms that coordinate the localization and translation of functionally linked mRNAs in axons.
Sponsorship
European Research Council (322817)
Identifiers
External DOI: https://doi.org/10.1016/j.conb.2018.02.025
This record's URL: https://www.repository.cam.ac.uk/handle/1810/287877
Rights
Licence:
http://creativecommons.org/licenses/by-nc-nd/4.0/
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