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Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Accepted version
Peer-reviewed

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Type

Article

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Authors

Evangelou, Evangelos 
Warren, Helen R 
Mosen-Ansorena, David 
Mifsud, Borbala 
Pazoki, Raha 

Abstract

High blood pressure is the foremost heritable global risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits to date (systolic, diastolic, pulse pressure) in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the potential for a precision medicine strategy for future cardiovascular disease prevention.

Description

Keywords

Adult, Aged, Aged, 80 and over, Blood Pressure, Cardiovascular Diseases, Cells, Cultured, Female, Genetic Loci, Genetic Predisposition to Disease, Genetic Testing, Genetics, Population, Genome-Wide Association Study, Human Umbilical Vein Endothelial Cells, Humans, Hypertension, Life Style, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors

Journal Title

Nature Genetics

Conference Name

Journal ISSN

1061-4036
1546-1718

Volume Title

50

Publisher

Springer Nature
Sponsorship
Medical Research Council (MC_UU_12015/1)
British Heart Foundation (None)
British Heart Foundation (None)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
MRC (MC_PC_13046)
MRC (MC_PC_13048)
Medical Research Council (G0401527)
Medical Research Council (G1000143)
Medical Research Council (MR/L003120/1)
Medical Research Council (MC_UU_12015/5)
Medical Research Council (MC_UU_12015/3)
Medical Research Council (MC_UU_12015/4)
Medical Research Council (MC_UU_12015/2)
Medical Research Council (MC_UU_12015/7)
Medical Research Council (MR/N003284/1)
Medical Research Council (MR/S003746/1)
Medical Research Council (MR/L016311/1)
Medical Research Council (MC_U106179471)