Genetic analysis of over one million people identifies 535 novel loci for blood pressure
Accepted version
Peer-reviewed
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Abstract
High blood pressure is the foremost heritable global risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits to date (systolic, diastolic, pulse pressure) in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the potential for a precision medicine strategy for future cardiovascular disease prevention.
Description
Keywords
Adult, Aged, Aged, 80 and over, Blood Pressure, Cardiovascular Diseases, Cells, Cultured, Female, Genetic Loci, Genetic Predisposition to Disease, Genetic Testing, Genetics, Population, Genome-Wide Association Study, Human Umbilical Vein Endothelial Cells, Humans, Hypertension, Life Style, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors
Journal Title
Nature Genetics
Conference Name
Journal ISSN
1061-4036
1546-1718
1546-1718
Volume Title
50
Publisher
Springer Nature
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Sponsorship
Medical Research Council (MC_UU_12015/1)
British Heart Foundation (None)
British Heart Foundation (None)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
MRC (MC_PC_13046)
MRC (MC_PC_13048)
Medical Research Council (G0401527)
Medical Research Council (G1000143)
Medical Research Council (MR/L003120/1)
Medical Research Council (MC_UU_12015/5)
Medical Research Council (MC_UU_12015/3)
Medical Research Council (MC_UU_12015/4)
Medical Research Council (MC_UU_12015/2)
Medical Research Council (MC_UU_12015/7)
Medical Research Council (MR/N003284/1)
Medical Research Council (MR/S003746/1)
Medical Research Council (MR/L016311/1)
Medical Research Council (MC_U106179471)
British Heart Foundation (None)
British Heart Foundation (None)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
MRC (MC_PC_13046)
MRC (MC_PC_13048)
Medical Research Council (G0401527)
Medical Research Council (G1000143)
Medical Research Council (MR/L003120/1)
Medical Research Council (MC_UU_12015/5)
Medical Research Council (MC_UU_12015/3)
Medical Research Council (MC_UU_12015/4)
Medical Research Council (MC_UU_12015/2)
Medical Research Council (MC_UU_12015/7)
Medical Research Council (MR/N003284/1)
Medical Research Council (MR/S003746/1)
Medical Research Council (MR/L016311/1)
Medical Research Council (MC_U106179471)