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dc.contributor.authorFitzgerald, Rebecca
dc.date.accessioned2019-01-16T00:30:40Z
dc.date.available2019-01-16T00:30:40Z
dc.identifier.issn1542-3565
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288022
dc.description.abstractBACKGROUND AND AIMS Diagnosis and surveillance of Barrett’s esophagus (BE) and eosinophilic esophagitis (EoE) have become emerging public health issues. Cytosponge® is a novel, minimally invasive esophageal cell collection device. We aimed to assess the data on safety and acceptability of this device. METHODS We performed a patient-level review of 5 prospective trials assessing Cytosponge® performance in patients with reflux disease, BE and EoE in primary and secondary care. Acceptability of Cytosponge® and subsequent endoscopy were recorded with visual analogue scale (VAS), wherein 0 and 10 denoted lowest and highest acceptability. Median VAS scores were compared using a Mann-Whitney test. The number of attempts, failures in swallowing the device and occurrence of adverse events were analyzed. Risk factors for failure in swallowing were analyzed using a multivariate regression model. RESULTS In total 2,672 Cytosponge® procedures were performed in 2,418 individuals between 2008 and 2017. There were two adverse events related to the device: a minor pharyngeal bleed and one case of detachment (<1:2,000). The median acceptability score for the Cytosponge® was 6.0 (IQR 5.0-8.0), which was higher than endoscopywithout sedation (median 5.0, IQR 3.0-7.0; p<0.001) and lower than endoscopy with sedation (median 8.0, IQR 5.0-9.0; p<0.001). Nearly all patients (91.1%) successfully swallowed the Cytosponge® and most (90.1%) were achieved with the first swallow attempt. Failure to swallow the device was more likely to occur in secondary care (OR= 5.13, 95%CI 1.48-17.79, P<0.01). CONCLUSIONS The Cytosponge® test is a safe procedure with good acceptability ratings in a variety of health care settings.
dc.publisherElsevier
dc.titleSafety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data from Individual Patients
dc.typeArticle
prism.endingPage656
prism.issueIdentifier4
prism.publicationNameClinical Gastroenterology and Hepatology
prism.startingPage647
prism.volume17
dc.identifier.doi10.17863/CAM.35341
dcterms.dateAccepted2018-07-28
rioxxterms.versionofrecord10.1016/j.cgh.2018.07.043
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07-28
dc.contributor.orcidFitzgerald, Rebecca [0000-0002-3434-3568]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research UK (C14478/A12088)
pubs.funder-project-idCancer Research Uk (None)
cam.issuedOnline2018-08-09
cam.orpheus.successTue Jun 16 10:40:27 BST 2020 - Embargo updated
cam.orpheus.counter12
rioxxterms.freetoread.startdate2019-08-09


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