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dc.contributor.authorZeiler, Frederick
dc.contributor.authorThelin, Eric
dc.contributor.authorDonnelly, Joseph
dc.contributor.authorStevens, A
dc.contributor.authorSmielewski, Peter
dc.contributor.authorCzosnyka, Marek
dc.contributor.authorHutchinson, Peter
dc.contributor.authorMenon, David
dc.date.accessioned2019-01-16T00:31:49Z
dc.date.available2019-01-16T00:31:49Z
dc.date.issued2019-01
dc.identifier.issn1759-4766
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288062
dc.description.abstractCerebral autoregulatory dysfunction after traumatic brain injury (TBI) is strongly linked to poor global outcome in patients at 6 months after injury. However, our understanding of what drives this dysfunction is limited. Genetic variation among individuals within a population gives rise to single nucleotide polymorphisms (SNPs) that have the potential to influence a given patient’s cerebrovascular response to an injury. Associations have been reported between a variety of genetic polymorphisms and global outcome in patients with TBI, but few studies have explored the association between genetics and cerebrovascular function after injury. In this Review, we explore polymorphisms that might play an important part in cerebral autoregulatory capacity after TBI. We outline a variety of SNPs, their biological substrates and their potential role in mediating cerebrovascular reactivity. A number of candidate polymorphisms exist in genes that are involved in myogenic, endothelial, metabolic and neurogenic vascular responses to injury. Furthermore, polymorphisms in genes involved in inflammation, the central autonomic response and spreading cortical depression might drive cerebrovascular reactivity. Identification of candidate genes involved in cerebral autoregulation after TBI provides a platform and rationale for further prospective investigation of the link between genetic polymorphisms and autoregulatory function.
dc.publisherSpringer Nature
dc.titleGenetic drivers of cerebral blood flow dysfunction in TBI: a speculative synthesis
dc.typeArticle
prism.endingPage39
prism.publicationNameNature Reviews Neurology
prism.startingPage25
prism.volume15
dc.identifier.doi10.17863/CAM.35381
dcterms.dateAccepted2018-10-05
rioxxterms.versionofrecord10.1038/s41582-018-0105-9
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10-05
dc.contributor.orcidZeiler, Frederick [0000-0003-1737-0510]
dc.contributor.orcidThelin, Eric [0000-0002-2338-4364]
dc.contributor.orcidDonnelly, Joseph [0000-0002-6502-8069]
dc.contributor.orcidSmielewski, Peter [0000-0001-5096-3938]
dc.contributor.orcidCzosnyka, Marek [0000-0003-2446-8006]
dc.contributor.orcidHutchinson, Peter [0000-0002-2796-1835]
dc.contributor.orcidMenon, David [0000-0002-3228-9692]
dc.identifier.eissn1759-4766
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G0601025)
pubs.funder-project-idMedical Research Council (G1002277)
pubs.funder-project-idMedical Research Council (G0600986)
pubs.funder-project-idMedical Research Council (G9439390)
pubs.funder-project-idNETSCC (None)
pubs.funder-project-idNETSCC (None)
pubs.funder-project-idTCC (None)
cam.issuedOnline2018-12-13
cam.orpheus.successTue Jun 16 10:40:30 BST 2020 - Embargo updated
cam.orpheus.counter12
rioxxterms.freetoread.startdate2019-07-31


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