Repository logo
 

Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Cahill, Emma N 

Abstract

Extinction within the reconsolidation window, or 'retrieval-extinction', has received much research interest as a possible technique for targeting the reconsolidation of maladaptive memories with a behavioural intervention. However, it remains to be determined whether the retrieval-extinction effect-a long-term reduction in fear behaviour, which appears resistant to spontaneous recovery, renewal and reinstatement-depends specifically on destabilisation of the original memory (the 'reconsolidation-update' account) or represents facilitation of an extinction memory (the 'extinction-facilitation' account). We propose that comparing the neurotransmitter systems, receptors and intracellular signalling pathways recruited by reconsolidation, extinction and retrieval-extinction will provide a way of distinguishing between these accounts.

Description

Keywords

Behaviour, Extinction, Memory, Reconsolidation, Retrieval-Extinction, Animals, Conditioning, Psychological, Extinction, Psychological, Fear, Humans, Memory, Receptors, Dopamine, Receptors, N-Methyl-D-Aspartate

Journal Title

Psychopharmacology (Berl)

Conference Name

Journal ISSN

0033-3158
1432-2072

Volume Title

236

Publisher

Springer Science and Business Media LLC
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M01407X/1)
Medical Research Council (MR/N02530X/1)