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dc.contributor.authorCahill, Emmaen
dc.contributor.authorMilton, Amyen
dc.date.accessioned2019-01-18T00:30:19Z
dc.date.available2019-01-18T00:30:19Z
dc.date.issued2019-01-17en
dc.identifier.issn0033-3158
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288139
dc.description.abstractExtinction within the reconsolidation window, or ‘retrieval-extinction’, has received much research interest as a possible technique for targeting the reconsolidation of maladaptive memories with a behavioural intervention. However, it remains to be determined whether the retrieval-extinction effect – a long-term reduction in fear behaviour, that appears resistant to spontaneous recovery, renewal and reinstatement - depends specifically on destabilisation of the original memory (the ‘reconsolidation-update’ account) or represents facilitation of an extinction memory (the ‘extinction-facilitation’ account). We propose that comparing the neurotransmitter systems, receptors and intracellular signalling pathways recruited by reconsolidation, extinction and retrieval-extinction will provide a way of distinguishing between these accounts.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectReceptors, Dopamineen
dc.subjectReceptors, N-Methyl-D-Aspartateen
dc.subjectFearen
dc.subjectConditioning (Psychology)en
dc.subjectMemoryen
dc.subjectExtinction, Psychologicalen
dc.titleNeurochemical and molecular mechanisms underlying the retrieval-extinction effect.en
dc.typeArticle
prism.endingPage132
prism.issueIdentifier1en
prism.publicationDate2019en
prism.publicationNamePsychopharmacologyen
prism.startingPage111
prism.volume236en
dc.identifier.doi10.17863/CAM.35455
dcterms.dateAccepted2018-11-12en
rioxxterms.versionofrecord10.1007/s00213-018-5121-3en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-01-17en
dc.contributor.orcidCahill, Emma [0000-0003-3054-1708]
dc.contributor.orcidMilton, Amy [0000-0003-0175-9417]
dc.identifier.eissn1432-2072
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/M01407X/1)
pubs.funder-project-idMRC (MR/N02530X/1)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International