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dc.contributor.authorKitadate, Yuen
dc.contributor.authorJörg, David Jen
dc.contributor.authorTokue, Moeen
dc.contributor.authorMaruyama, Ayumien
dc.contributor.authorIchikawa, Rieen
dc.contributor.authorTsuchiya, Sokenen
dc.contributor.authorSegi-Nishida, Erien
dc.contributor.authorNakagawa, Toshinorien
dc.contributor.authorUchida, Ayaen
dc.contributor.authorKimura-Yoshida, Chiharuen
dc.contributor.authorMizuno, Seiyaen
dc.contributor.authorSugiyama, Fumihiroen
dc.contributor.authorAzami, Takuyaen
dc.contributor.authorEma, Masatsuguen
dc.contributor.authorNoda, Chiyoen
dc.contributor.authorKobayashi, Satoruen
dc.contributor.authorMatsuo, Isaoen
dc.contributor.authorKanai, Yoshiakiraen
dc.contributor.authorNagasawa, Takashien
dc.contributor.authorSugimoto, Yukihikoen
dc.contributor.authorTakahashi, Satoruen
dc.contributor.authorSimons, Benjaminen
dc.contributor.authorYoshida, Shoseien
dc.date.accessioned2019-01-18T00:30:21Z
dc.date.available2019-01-18T00:30:21Z
dc.date.issued2019-01en
dc.identifier.issn1934-5909
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288140
dc.description.abstractIn many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically-defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogenic stem cell density is tightly regulated by the supply of fibroblast growth factors (FGFs) from lymphatic endothelial cells. We propose that stem cell homeostasis is achieved through competition for a limited supply of FGFs. We show that the quantitative dependence of stem cell density on FGF dosage, the biased localization of stem cells towards FGF sources, and stem cell dynamics during regeneration following injury can all be predicted and explained within the framework of a minimal theoretical model based on “mitogen competition”. We propose that this model provides a generic and robust mechanism to support stem cell homeostasis in open, or facultative, niche environments.
dc.description.sponsorshipWellcome Trust
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSpermatozoaen
dc.subjectStem Cellsen
dc.subjectAnimalsen
dc.subjectMice, Inbred C57BLen
dc.subjectMice, Knockouten
dc.subjectMiceen
dc.subjectMitogensen
dc.subjectCell Differentiationen
dc.subjectSpermatogenesisen
dc.subjectHomeostasisen
dc.subjectMaleen
dc.subjectGlial Cell Line-Derived Neurotrophic Factor Receptorsen
dc.subjectFibroblast Growth Factor 5en
dc.subjectCell Self Renewalen
dc.titleCompetition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.en
dc.typeArticle
prism.endingPage92.e6
prism.issueIdentifier1en
prism.publicationDate2019en
prism.publicationNameCell stem cellen
prism.startingPage79
prism.volume24en
dc.identifier.doi10.17863/CAM.35456
dcterms.dateAccepted2018-11-09en
rioxxterms.versionofrecord10.1016/j.stem.2018.11.013en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-01en
dc.contributor.orcidJörg, David J [0000-0001-5960-0260]
dc.contributor.orcidNakagawa, Toshinori [0000-0001-7620-1720]
dc.contributor.orcidAzami, Takuya [0000-0002-3759-9710]
dc.contributor.orcidEma, Masatsugu [0000-0003-0645-6183]
dc.contributor.orcidMatsuo, Isao [0000-0002-5916-6246]
dc.contributor.orcidNagasawa, Takashi [0000-0002-1085-0960]
dc.contributor.orcidSimons, Benjamin [0000-0002-3875-7071]
dc.contributor.orcidYoshida, Shosei [0000-0001-8861-1866]
dc.identifier.eissn1875-9777
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (098357/Z/12/Z)
pubs.funder-project-idRoyal Society (RP/R1/180165)
pubs.funder-project-idMRC (MC_PC_12009)
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
pubs.funder-project-idCancer Research UK (A14492)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International