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dc.contributor.authorProctor, Christopher
dc.contributor.authorUguz, Ilke
dc.contributor.authorSlezia, Andrea
dc.contributor.authorCurto, Vincenzo
dc.contributor.authorInal, Sahika
dc.contributor.authorWilliamson, Adam
dc.contributor.authorMalliaras, George
dc.date.accessioned2019-01-18T00:31:10Z
dc.date.available2019-01-18T00:31:10Z
dc.date.issued2019-02-12
dc.identifier.issn2366-7478
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288168
dc.description.abstractThe challenge of treating neurological disorders has motivated the development of implantable devices that can deliver treatment when and where it’s needed. This study presents a novel brain implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.
dc.publisherWilkey
dc.titleAn Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo
dc.typeArticle
prism.issueIdentifier2
prism.number1800270
prism.publicationDate2019
prism.publicationNameAdvanced Biosystems
prism.volume3
dc.identifier.doi10.17863/CAM.35484
dcterms.dateAccepted2018-11-15
rioxxterms.versionofrecord10.1002/adbi.201800270
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-02-12
dc.contributor.orcidProctor, Christopher [0000-0002-2066-1354]
dc.contributor.orcidMalliaras, George [0000-0002-4582-8501]
dc.identifier.eissn2366-7478
dc.publisher.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/adbi.201800270
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-11-27
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/adbi.201800270
rioxxterms.freetoread.startdate2019-11-27


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