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dc.contributor.authorTakahashi, Nozomi
dc.contributor.authorColuccio, Andrea
dc.contributor.authorThorball, Christian W
dc.contributor.authorPlanet, Evarist
dc.contributor.authorShi, Hui
dc.contributor.authorOffner, Sandra
dc.contributor.authorTurelli, Priscilla
dc.contributor.authorImbeault, Michael
dc.contributor.authorFerguson-Smith, Anne C
dc.contributor.authorTrono, Didier
dc.date.accessioned2019-01-18T00:31:21Z
dc.date.available2019-01-18T00:31:21Z
dc.date.issued2019-01-01
dc.identifier.issn0890-9369
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288175
dc.description.abstractGenomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertilization reprogramming, yet incomplete penetrance of ZFP57 mutations in humans and mice suggests additional effectors. We reveal that ZNF445/ZFP445, which we trace to the origins of imprinting, binds imprinting control regions (ICRs) in mice and humans. In mice, ZFP445 and ZFP57 act together, maintaining all but one ICR in vivo, whereas earlier embryonic expression of ZNF445 and its intolerance to loss-of-function mutations indicate greater importance in the maintenance of human imprints.
dc.format.mediumPrint
dc.languageeng
dc.publisherCold Spring Harbor Laboratory
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCells, Cultured
dc.subjectAnimals
dc.subjectMice, Inbred C57BL
dc.subjectHumans
dc.subjectMice
dc.subjectTranscription Factors
dc.subjectRepressor Proteins
dc.subjectDNA Methylation
dc.subjectGenomic Imprinting
dc.subjectConserved Sequence
dc.subjectKruppel-Like Transcription Factors
dc.subjectEmbryonic Stem Cells
dc.subjectHEK293 Cells
dc.titleZNF445 is a primary regulator of genomic imprinting.
dc.typeArticle
prism.endingPage54
prism.issueIdentifier1-2
prism.publicationDate2019
prism.publicationNameGenes Dev
prism.startingPage49
prism.volume33
dc.identifier.doi10.17863/CAM.35491
dcterms.dateAccepted2018-11-07
rioxxterms.versionofrecord10.1101/gad.320069.118
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-01
dc.contributor.orcidTakahashi, Nozomi [0000-0002-4267-1094]
dc.contributor.orcidImbeault, Michael [0000-0002-0073-0922]
dc.contributor.orcidFerguson-Smith, Anne [0000-0003-4996-9990]
dc.identifier.eissn1549-5477
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/J001597/1)
pubs.funder-project-idWellcome Trust (095606/Z/11/Z)
pubs.funder-project-idEuropean Commission (290123)
pubs.funder-project-idMedical Research Council (MR/R009791/1)
cam.issuedOnline2019-01-02


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International