ZNF445 is a primary regulator of genomic imprinting.
dc.contributor.author | Takahashi, Nozomi | |
dc.contributor.author | Coluccio, Andrea | |
dc.contributor.author | Thorball, Christian W | |
dc.contributor.author | Planet, Evarist | |
dc.contributor.author | Shi, Hui | |
dc.contributor.author | Offner, Sandra | |
dc.contributor.author | Turelli, Priscilla | |
dc.contributor.author | Imbeault, Michael | |
dc.contributor.author | Ferguson-Smith, Anne | |
dc.contributor.author | Trono, Didier | |
dc.date.accessioned | 2019-01-18T00:31:21Z | |
dc.date.available | 2019-01-18T00:31:21Z | |
dc.date.issued | 2019-01-01 | |
dc.identifier.issn | 0890-9369 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/288175 | |
dc.description.abstract | Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertilization reprogramming, yet incomplete penetrance of ZFP57 mutations in humans and mice suggests additional effectors. We reveal that ZNF445/ZFP445, which we trace to the origins of imprinting, binds imprinting control regions (ICRs) in mice and humans. In mice, ZFP445 and ZFP57 act together, maintaining all but one ICR in vivo, whereas earlier embryonic expression of ZNF445 and its intolerance to loss-of-function mutations indicate greater importance in the maintenance of human imprints. | |
dc.format.medium | ||
dc.language | eng | |
dc.publisher | Cold Spring Harbor Laboratory | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Cells, Cultured | |
dc.subject | Animals | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Humans | |
dc.subject | Mice | |
dc.subject | Transcription Factors | |
dc.subject | Repressor Proteins | |
dc.subject | DNA Methylation | |
dc.subject | Genomic Imprinting | |
dc.subject | Conserved Sequence | |
dc.subject | Kruppel-Like Transcription Factors | |
dc.subject | Embryonic Stem Cells | |
dc.subject | HEK293 Cells | |
dc.title | ZNF445 is a primary regulator of genomic imprinting. | |
dc.type | Article | |
prism.endingPage | 54 | |
prism.issueIdentifier | 1-2 | |
prism.publicationDate | 2019 | |
prism.publicationName | Genes Dev | |
prism.startingPage | 49 | |
prism.volume | 33 | |
dc.identifier.doi | 10.17863/CAM.35491 | |
dcterms.dateAccepted | 2018-11-07 | |
rioxxterms.versionofrecord | 10.1101/gad.320069.118 | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2019-01 | |
dc.contributor.orcid | Takahashi, Nozomi [0000-0002-4267-1094] | |
dc.contributor.orcid | Imbeault, Michael [0000-0002-0073-0922] | |
dc.contributor.orcid | Ferguson-Smith, Anne [0000-0003-4996-9990] | |
dc.identifier.eissn | 1549-5477 | |
rioxxterms.type | Journal Article/Review | |
pubs.funder-project-id | Medical Research Council (MR/J001597/1) | |
pubs.funder-project-id | Wellcome Trust (095606/Z/11/Z) | |
pubs.funder-project-id | European Commission (290123) | |
pubs.funder-project-id | Medical Research Council (MR/R009791/1) | |
cam.issuedOnline | 2019-01-02 |
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