Multimodal imaging of brain connectivity reveals predictors of individual decision strategy in statistical learning.
Vértes, Petra E
Welchman, Andrew E
Nat Hum Behav
Springer Science and Business Media LLC
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Karlaftis, V. M., Giorgio, J., Vértes, P. E., Wang, R., Shen, Y., Tino, P., Welchman, A. E., & et al. (2019). Multimodal imaging of brain connectivity reveals predictors of individual decision strategy in statistical learning.. Nat Hum Behav, 3 297-307. https://doi.org/10.1038/s41562-018-0503-4
Successful human behaviour depends on the brain's ability to extract meaningful structure from information streams and make predictions about future events. Individuals can differ markedly in the decision strategies they use to learn the environment's statistics, yet we have little idea why. Here, we investigate whether the brain networks involved in learning temporal sequences without explicit reward differ depending on the decision strategy that individuals adopt. We demonstrate that individuals alter their decision strategy in response to changes in temporal statistics and engage dissociable circuits: extracting the exact sequence statistics relates to plasticity in motor corticostriatal circuits, while selecting the most probable outcomes relates to plasticity in visual, motivational and executive corticostriatal circuits. Combining graph metrics of functional and structural connectivity, we provide evidence that learning-dependent changes in these circuits predict individual decision strategy. Our findings propose brain plasticity mechanisms that mediate individual ability for interpreting the structure of variable environments.
Is supplemented by: https://doi.org/10.17863/CAM.34876
Related research output: https://doi.org/10.17863/CAM.34876
This work was supported by grants to ZK from the Biotechnology and Biological Sciences Research Council (H012508 and BB/P021255/1), the Leverhulme Trust (RF-2011-811 378), the Alan Turing Institute (TU/B/000095), the Wellcome Trust (205067/Z/16/Z) and the [European Community's] Seventh Framework Programme [FP7/2007-2013] under agreement PITN-GA-2011-290011, AEW from the Wellcome Trust (095183/Z/10/Z) and the [European Community's] Seventh Framework Programme [FP7/2007-2013] under agreement PITN-GA-2012-316746, PT from Engineering and Physical Sciences Research Council (EP/L000296/1), PEV from the MRC (MR/K020706/1).
European Commission (290011)
Leverhulme Trust (RF-2011-378)
European Commission (316746)
Wellcome Trust (205067/Z/16/Z)
Biotechnology and Biological Sciences Research Council (BB/P021255/1)
Alan Turing Institute (EP/N510129/1)
MQ: Transforming Mental Health (MQ17-24 Vertes)
Medical Research Council (MR/K020706/1)
Wellcome Trust (095183/Z/10/Z)
External DOI: https://doi.org/10.1038/s41562-018-0503-4
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288195