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dc.contributor.authorYamurai Bishi, Lorraine
dc.contributor.authorChaitanya Vedithi, Sundeep
dc.contributor.authorL. Blundell, Tom
dc.contributor.authorChitima Mugumbate, Grace
dc.date.accessioned2019-01-18T00:32:02Z
dc.date.available2019-01-18T00:32:02Z
dc.date.issued2019-02-01
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288199
dc.description.abstractTuberculosis (TB) continues to be a major health hazard worldwide due to the resurgence of drug discovery strains of Mycobacterium tuberculosis (Mtb) and co-infection. For decades drug discovery has concentrated on identifying ligands for ~10 Mtb targets, hence most of the identified essential proteins are not utilised in TB chemotherapy. Here computational techniques were used to identify ligands for the orphan Mtb proteins. These range from ligand-based and structure-based virtual screening modelling the proteome of the bacterium. Identification of ligands for most of the Mtb Proteins will provide novel TB drugs and targets and hence address drug resistance, toxicity and the duration of TB treatment
dc.description.sponsorshipGates Foundation, Cystic Fibrosis Trust and American Leprosy Missions
dc.publisherIntechOpen
dc.titleComputational Deorphaning of <i>Mycobacterium tuberculosis</i> Targets
dc.typeArticle
prism.publicationNameIntechOpen
dc.identifier.doi10.17863/CAM.35515
dcterms.dateAccepted2018-11-05
rioxxterms.versionofrecord10.5772/intechopen.82374
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2018-11-05
rioxxterms.typeJournal Article/Review
pubs.funder-project-idAmerican Leprosy Missions (unknown)
pubs.funder-project-idBill & Melinda Gates Foundation (via Foundation for the National Institutes of Health (FNIH)) (BLUN17STB)
pubs.funder-project-idCystic Fibrosis Trust (SRC 010)
cam.issuedOnline2020-03-11
cam.orpheus.successThu Jan 30 10:53:31 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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