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dc.contributor.authorGregson, Johnen
dc.contributor.authorKaptoge, Stephenen
dc.contributor.authorBolton, Thomasen
dc.contributor.authorPennells, Lisaen
dc.contributor.authorWilleit, Peteren
dc.contributor.authorBurgess, Stephenen
dc.contributor.authorBell, Stevenen
dc.contributor.authorSweeting, Michaelen
dc.contributor.authorRimm, Eric Ben
dc.contributor.authorKabrhel, Christopheren
dc.contributor.authorZöller, Bengten
dc.contributor.authorWassertheil-Smoller, Sylviaen
dc.contributor.authorLowe, Gordon DOen
dc.contributor.authorWood, Angelaen
dc.contributor.authorButterworth, Adamen
dc.contributor.authorThompson, Simon Gen
dc.contributor.authorDanesh, Johnen
dc.contributor.authorDi Angelantonio, Emanueleen
dc.contributor.authorMeade, Tomen
dc.date.accessioned2019-01-18T00:32:18Z
dc.date.available2019-01-18T00:32:18Z
dc.date.issued2019-02en
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288209
dc.description.abstractImportance It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE). Objective To estimate associations between major cardiovascular risk factors and VTE, i.e., deep-vein thrombosis (DVT) and pulmonary embolism (PE). Design Analysis of individual-participant data from the Emerging Risk Factors Collaboration (ERFC; 731,728 participants; 75 cohorts; latest date of follow-up 2015), and UK Biobank (UKBB; 421,537 participants; latest date of follow-up 2016). Setting Approximately population-based prospective cohort studies. Participants Individuals without cardiovascular disease at baseline. Exposures A panel of several established cardiovascular risk factors. Main Outcomes and Measures Hazard ratios (HRs) per 1-SD higher risk factor levels (or presence/absence). Incident fatal outcomes in ERFC (n=1041 VTE, n=25,131 CHD) and incident fatal/non-fatal outcomes in UKBB (n=2321 VTE, n=3385 CHD). HRs were adjusted for age, sex, smoking status, diabetes mellitus, and body-mass index. Results Adjusted HRs for VTE were: 2.67 (2.45-2.91) in ERFC and 1.81 (1.71-1.92) in UKBB per decade older age; 1.38 (1.20-1.58) in ERFC and 1.23 (1.08-1.40) in UKBB with smoking; 1.43 (1.35-1.50) in ERFC and 1.37 (1.32-1.41) in UKBB per 1-SD higher body-mass index; and 0.75 (0.61-0.93) in ERFC and 0.82 (0.71-0.94) in UKBB with current alcohol consumption. For the preceding factors, there were similar HRs for pulmonary embolism versus deep vein thrombosis in UKBB (except adiposity was more strongly associated with PE; P<0.01), and similar HRs for unprovoked versus provoked VTE. Apart from adiposity, these risk factors were less strongly associated with VTE than coronary heart disease. We noted inconsistent associations with diabetes and blood pressure for VTEs across ERFC and UKBB, and had limited ability to study lipid and inflammation markers. Conclusions and Relevance Older age, smoking, adiposity, and lower alcohol consumption were consistently associated with higher VTE risk.
dc.description.sponsorshipA study website (http://www.phpc.cam.ac.uk/ceu/erfc/list-of-studies/) includes a list that investigators have provided of funding agencies that have supported individual cohorts in the ERFC contributing to the present consortium. This research has been conducted using the UK Biobank resource (application 26865).
dc.rightsAttribution 4.0 International (CC BY)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleCardiovascular Risk Factors Associated With Venous Thromboembolismen
dc.typeArticle
prism.issueIdentifier2en
prism.number10.1001/jamacardio.2018.4537en
prism.publicationDate2019en
prism.publicationNameJAMA Cardiologyen
prism.volume1en
dc.identifier.doi10.17863/CAM.35525
dcterms.dateAccepted2018-11-19en
rioxxterms.versionofrecord10.1001/jamacardio.2018.4537en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-02en
dc.contributor.orcidKaptoge, Stephen [0000-0002-1155-4872]
dc.contributor.orcidPennells, Lisa [0000-0002-8594-3061]
dc.contributor.orcidBurgess, Stephen [0000-0001-5365-8760]
dc.contributor.orcidWood, Angela [0000-0002-7937-304X]
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.contributor.orcidDanesh, John [0000-0003-1158-6791]
dc.contributor.orcidDi Angelantonio, Emanuele [0000-0001-8776-6719]
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-01-16en
cam.orpheus.successTue Jun 16 10:40:36 BST 2020 - The item has an open VoR version.*
cam.orpheus.counter12*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International (CC BY)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY)