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dc.contributor.authorMyint, Phyo Kyawen
dc.contributor.authorWilson, Andrew Men
dc.contributor.authorClark, Allan Ben
dc.contributor.authorLuben, Roberten
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorKhaw, Kay-Teeen
dc.date.accessioned2019-01-22T00:30:09Z
dc.date.available2019-01-22T00:30:09Z
dc.date.issued2019-11en
dc.identifier.issn0954-3007
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288275
dc.description.abstractAbstract Background: Cancerous and non-cancerous respiratory diseases are common and contribute significantly to global disease burden. We aim to quantify the association between plasma vitamin C concentrations as an indicator of high fruit and vegetable consumption and the risk of incident respiratory diseases and associated mortality in a general population. Methods: 19,357 men and women aged 40-79 years without prevalent respiratory diseases at the baseline (1993-1997) and participating in the European Prospective Investigation into Cancer (EPIC)-Norfolk study in the UK were followed through March 2015 for both incidence and mortality from respiratory diseases. Results: There were a total of 3914 incident events and 407 deaths due to any respiratory diseases (excluding lung cancers), 367 incident lung cancers and 280 lung cancer deaths during the follow up (total person years >300,000 years). Cox proportional hazards models showed, persons in the top quartiles of baseline plasma vitamin C concentrations had a 43% lower risk of lung cancer (HR 0.57; 95%CI:0.41-0.81) than did those in the bottom quartile, independently of potential confounders. The results are similar for non-cancerous any respiratory disease (HR 0.85;0.77-0.95), chronic respiratory diseases (HR0.81;0.69-0.96), and pneumonia (HR0.70;0.59-0.83). The corresponding values for mortality were 0.54(0.35- 0.81), 0.81(0.59-1.12), 0.85(0.44-1.66), and 0.61(0.37-1.01), respectively. Confining analyses to non-smokers showed 42% and 53% risk reduction of non-smoking related lung cancers incidence and death. Conclusions: Higher levels of vitamin C concentrations as a marker of high fruit and vegetable consumption reduces the risk of cancerous and non-cancerous respiratory illnesses including non-smoking related cancers incidence and deaths.
dc.description.sponsorshipThe authors would like to thank the participants of the EPIC-Norfolk cohort. We thank the nutritionist team and data management team of the EPIC-Norfolk cohort. The EPIC-Norfolk study was supported by grants from the Medical Research Council and Cancer Research UK. Funders and sponsors had no role in design and the data collection, analysis, and interpretation of data and the writing of the article and the decision to submit it for publication.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.subjectHumansen
dc.subjectRespiratory Tract Diseasesen
dc.subjectAscorbic Aciden
dc.subjectRisk Factorsen
dc.subjectProspective Studiesen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.titlePlasma vitamin C concentrations and risk of incident respiratory diseases and mortality in the European Prospective Investigation into Cancer-Norfolk population-based cohort study.en
dc.typeArticle
prism.endingPage1500
prism.issueIdentifier11en
prism.publicationDate2019en
prism.publicationNameEuropean journal of clinical nutritionen
prism.startingPage1492
prism.volume73en
dc.identifier.doi10.17863/CAM.35591
dcterms.dateAccepted2018-11-22en
rioxxterms.versionofrecord10.1038/s41430-019-0393-1en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-11en
dc.contributor.orcidMyint, Phyo Kyaw [0000-0003-3852-6158]
dc.contributor.orcidClark, Allan B [0000-0003-2965-8941]
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1476-5640
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/N003284/1)
rioxxterms.freetoread.startdate2019-07-31


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